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ACUTE ARTICULAR RHEUMATISM. [PDF]

JAMA: The Journal of the American Medical Association, 1906
This paper does not assume the pretension of being a complete discussion of this disease, and only a few of the most important points in the general discussion, diagnosis, differential diagnosis, etiology and treatment, are discussed. The statements here made are the result of a large clinical experience extending over a period of fourteen years ...
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

A Clinical Study of Decellularized Tissue Engineering Hyaline Cartilage Graft (dLhCG) for Articular Cartilage Repair

Advanced Science, EarlyView.
ABSTRACT Current clinical approaches for knee cartilage repair are often limited by hypertrophy and fibrosis in the regenerated tissues. A decellularized tissue‐engineered hyaline cartilage graft (dLhCG), composed of a type II collagen‐based extracellular matrix, has been developed to overcome this limitation.
Zhen Zhang, Gong Cheng, Wenyong Fei, Qiuzhen Liang, Liang Zhang, Kegui Liu, Jihang Dai, Bo Cong, Xu Hu, Zhonglian Wu, Jialu Zhang, Jinlan Cui, Hang Yao, Dong‐An Wang, Jingcheng Wang, Tao Sun, Jiang Zheng   +16 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Anterior cruciate ligament reconstruction with the peroneus longus tendon

Acta Orthopaedica et Traumatologica Turcica, 2020
Objectives: The aim of the study was to evaluate the results of anterior cruciate ligament (ACL) reconstruction using a peroneus longus tendon (PLT) autograft.\r\nMethods: The study included 29 patients (27 males, 2 females; mean age 30 years; range 21 ...
Servet Kerimoglu, Osman Aynaci, Metehan Saracoglu, Hafiz Aydin, Ahmet Ugur Turhan   +4 more
doaj  

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Quadriceps tendon ruptures: Evaluation and treatment

Acta Orthopaedica et Traumatologica Turcica, 2020
Objectives: We evaluated the patients who underwent surgical repair for rupture of the quadriceps tendon.\nMethods: Five patients (4 men, 1 woman; mean age 56 years; range 33 to 77 years) had rupture of the quadriceps tendon at the osteotendinous ...
Cem Zeki Esenyel, Kahraman Ozturk, Kamil Cetiner, Ridvan Yesiltepe, Ayhan Nedim Kara   +4 more
doaj  

Treatment of posterior locked fracture dislocation of the shoulder with hemiarthroplasty

Acta Orthopaedica et Traumatologica Turcica, 2021
Objectives: Functional results of hemiarthroplasty procedure in the treatment of patients with posterior locked fracture dislocation of the shoulder were evaluated.\nMethods: Five shoulders of four patients (3 men, 1 woman; mean age 62.25 years) who ...
Mustafa Ozkan, Onder Gul, Kadir Bacakoglu, Cem Ozcan, Ahmet Ekin   +4 more
doaj  

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Arthroscopic selective capsular release in the treatment of frozen shoulder

Acta Orthopaedica et Traumatologica Turcica, 2020
Objectives: We evaluated the results of arthroscopic selective capsular release in patients with frozen shoulder.\nMethods: Sixteen patients (5 males, 11 females; mean age 51 years; range 25 to 73 years) underwent arthroscopic capsular release for frozen
Mehmet Ugur Ozbaydar, Murat Tonbul, Mehmet Altun, Okan Yalaman   +3 more
doaj