Results 51 to 60 of about 769,096 (329)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

An inferential articulation of metaphorical assertions [PDF]

, 2019
This paper argues for the view that metaphors are assertions by locating metaphor within our social discursive practices of asserting and inferring. The literal and the metaphorical differ not in the stating of facts nor in the representation of states ...
Kwesi, Richmond
core  

Parkinson Disease Detection from Speech Articulation Neuromechanics

Front. Neuroinform., 2017
Aim: The research described is intended to give a description of articulation dynamics as a correlate of the kinematic behavior of the jaw-tongue biomechanical system, encoded as a probability distribution of an absolute joint velocity. This distribution
P. G. Vilda, J. Mekyska, J. M. Ferrández, D. Palacios-Alonso, A. Gómez-Rodellar, M. V. R. Biarge, Z. Galaz, Z. Smékal, I. Eliasova, M. Kostalova, I. Rektorová   +10 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Articulation or phonology? Evidence from longitudinal error data

Clinical Linguistics & Phonetics, 2018
Children’s speech difficulties can be motor (phone misarticulation) or linguistic (impaired knowledge of phonological contrasts and constraints). These two difficulties sometimes co-occur.
B. Dodd, S. Reilly, Kyriaki Ttofari Eecen, A. Morgan   +3 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

(re)Articulating Feminism

Nordicom Review, 2016
In this article we study campaign material of the Swedish party Feminist Initiative (FI) during the 2014 parliamentary election campaign in Sweden. Approaching the topic from discourse-theoretical and intersectional perspectives, we ask how the inclusion
Filimonov Kirill, Svensson Jakob
doaj   +1 more source

Enhancing partition crossover with articulation points analysis [PDF]

, 2018
Partition Crossover is a recombination operator for pseudo-Boolean optimization with the ability to explore an exponential number of solutions in linear or square time.
Chicano, Francisco, Ochoa, Gabriela, Tinós, Renato, Whitley, Darrell   +3 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source