Results 71 to 80 of about 244,421 (294)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hanau Articulator Training: Zeroing the Articulator

MedEdPORTAL, 2010
Abstract This self-paced online module shows the parts of a standard Hanau articulator, teaches students how to reset it to zero in preparation for mounting casts, and allows students to zero a virtual Hanau articulator. This Flash-based module is an excellent preparation for learning this basic laboratory instrument before beginning laboratory and/or ...
Emily Springfield, Mauricio Moeller
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The Interplay between Place, Culture, and Ideology in Steinbeck’s The Grapes of Wrath: A Reading in the light of Cultural Materialism [PDF]

Al-Mağallah Al-ʿilmiyyaẗ Li Kulliyyaẗ Al-Adāb - Ǧāmiʿaẗ Asyūṭ
Cultural materialism questions the modernist claims to timelessness and its tendency to set certain meanings as universal. Dealing with the particularity of incidents, cultural materialism introduces a type of cultural analysis that looks deeply into the
Alia Abbas M. Hassan Mabrouk
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Stimulation Techniques in Increasing Dysaudia Children's Ability to Speak Fonem Konsonan Apico Alveolar

Journal of ICSAR, 2020
The tongue is one of the most important articulators in the language of sound. The tongue makes various sounds, both vowels, and consonants, that produce words and sentences.
Santi Komaladini
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Spectrographs Speech Measures and Audiologic Findings of Young Children with Unilateral Cleft Lip and Palate

Turkish Journal of Orthodontics, 2008
The aim of the study was to assess the audiologic and the speech status of operated unilateral cleft preschooler patients who have no orthodontic, otologic, and speech therapy.
Fatih Ögüt, Gökhan Önçağ, Servet Doğan, Erkan Zeki Engin, M. Akif Kılıç   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Using Modern Conducting Approaches in the Performance of Classical Repertoire

Studia Universitatis Babeş-Bolyai. Musica
The study aims to reveal the conducting techniques as a complex unified system. Its components are profoundly interconnected and have inherent functions, content and significance.
Vasyl CHUCHMAN, Anastasiia PATER, Vira NAIDA, Iryna PARFENTIEVA, Liubomyr MARTYNIV   +4 more
doaj   +1 more source