Results 81 to 90 of about 249,022 (295)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Transdisciplinary Articulations [PDF]

Scenario: A Journal of Performative Teaching, Learning, Research, 2018
O'Gorman, Róisín, Woodhouse, Fionn   +1 more
openaire   +3 more sources

Articulation marks in string playing: Bach interpretation articulation marks in primary sources of J. S. Bach [PDF]

, 1998
Es una traducción de: Articulation marks in string playing. "Bach interpretation articulation marks in primary sources of J. S. Bach" (1990). Cambridge University Press; págs. 35-46.Ramón Silles (traductor)
Butt, John
core   +1 more source

On the Divergence of a Proto-Indo-European Velar Syllabic Nasal in Indo-European Languages

Дискурс, 2019
Introduction. The proposed article critically examines the explanation of the origin of nasal vowels in Slavic languages by incorporating an open syllable law.
G. M. Telezhko
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The C/D Model and the Effect of Prosodic Structure on Articulation

Languages
The Converter/Distributor (C/D) model, as proposed by Fujimura is theoretically grounded on articulatory observations of X-ray microbeam (XRMB) data that show that utterance syllable prominence patterns “dictate” the size, timing and phrasing of ...
Donna Mae Erickson
doaj   +1 more source

The Role of Temporal Modulation in Sensorimotor Interaction

Frontiers in Psychology, 2019
How do we align the distinct neural patterns associated with the articulation and the acoustics of the same utterance in order to guide behaviors that demand sensorimotor interaction, such as vocal learning and the use of feedback during speech ...
Louis Goldstein
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Learner Motivation and Teaching Aims of Japanese Language Instruction in Slovenia

Acta Linguistica Asiatica, 2018
The purpose of this paper is to describe Japanese language teaching and the role of language teachers in Slovenia. Firstly, this paper shows the development and current situation of Japanese language teaching in Slovenia and Central Eastern Europe based ...
Nagisa MORITOKI ŠKOF
doaj   +1 more source