Results 101 to 110 of about 181,305 (313)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Modeling Dimensions of Prosodic Prominence

Frontiers in Communication, 2019
Detailed modifications both in the laryngeal as well as in the supra-laryngeal domain have been shown to be used by speakers of German to express prosodic prominence.
Simon Roessig, Doris Mücke
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

An Interface for Open-Ended Design in Housing Production: An Analysis of Yeşilköy Housing by the Context of Adaptability

Journal of Architectural Sciences and Applications
Housing can be regarded as a field of production that directly reflects changes in individual life while serving as a significant indicator of broader social transformations. This study conceptualizes housing as an open-ended product within the framework
Güldehan Atay, Melike Yenice Yıldız
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Causes for articulation diisorders [PDF]

, 2012
The aim of the thesis is to distinguish possible anatomical organic causes for the articulation disorder in the medium-sized set of children aged 5 years.
Križnar, Lidija
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La médiatisation des mères infanticides et l’idéal de « bonne mère »

Revue Française des Sciences de l’Information et de la Communication
This article focuses on the media coverage of mothers who murdered their children in French national television news programs between 1985 and 2015.
Sophie Dubec
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Articulation et collaboration entre les équipes pédagogiques et les services de documentation Conclusions du groupe de travail – juillet 2016 [PDF]

Conclusions du groupe de travail composé de représentants de réseaux d’enseignants, d’étudiants, des services d’appui, des bibliothèques, de l’IGB et de l’Enssib.
Groupe de travail "Articulation et collaboration entre les équipes pédagogiques et les services de documentation"
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