Results 51 to 60 of about 244,421 (294)

Relationship between phonemic discrimination ability and articulation in cochlear implanted preschool children [PDF]

open access: yesSpecijalna Edukacija i Rehabilitacija
Introduction. The acquisition of the native language is achieved through mastering the phonological system, which relies on the development of phonemic discrimination and articulation. Objectives.
Bjelić Marija P.   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Displacement and Articulation Rhetoric in Sa'adi's Golestān [PDF]

open access: yesمطالعات زبانی و بلاغی
In every text, there are two levels of ambiguity of translation and ratio, which are the basis of the rhetorical explanation of the text from different perspectives of textual analysis, whether formalistic or discursive.
Omer Mohammad Saeed   +1 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Adolescent fathers and mothers in the parenting exercise

open access: yesCiencia y Cuidado, 2017
Introduction: In general, parenting has been considered as the actions of socialization led by adults, which consider teenagers as unable people to achieve trajectories of the expected ideal development for girls and boys; on the other side the State ...
Doris Amparo Parada-Rico   +1 more
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Russian phonetics teaching difficulties to foreign students

open access: yesНеофилология, 2019
In this study we consider the important issues of work on the phonetic structure of the language at the initial stage of foreign students teaching, the actual problems of teaching Russian phonetics to foreign students, the peculiarities of development ...
Ella E. Shcherbatyuk
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

In the workplace: learning as articulation work, and doing articulation work to understand learning [PDF]

open access: yes, 2007
This paper offers an account of a methodological approach to understanding and developing learning that has been successfully used in a research project on mathematical skills in workplaces.
Kent, Phillip
core   +1 more source

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