Results 91 to 100 of about 5,372,669 (352)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Artificial turf developments and sport applications at Ghent University [PDF]

, 2019
In the past decades artificial turf fields have developed into a worthy alternative for natural grass in outdoor sports appliance such as football, rugby and hockey. Heavy rainfall and periods of drought can affect a natural pitch.
D'hooge, Dagmar, Kiekens, Paul, Rambour, Stijn   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Relationship between Respiratory Indexes with the Consequences of Weaning from Mechanical Ventilator in CABG Patients in ShahidRajaei Hospital, Tehran, Iran, 2011

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives:Weaning a patient from mechanical ventilator is a critical step in the process of treatment at CCU which takes a long time of mechanical ventilation.
Mitra Khoobi, Majid Ahmady Hedayat, Nooredin Mohammady, Mansooreh Ashghali Farahani, Hamid Haghani, Arash Anisiyan   +5 more
doaj  

Male perineal sling with autologous aponeurosis and bone fixation: description of a technical modification

International Brazilian Journal of Urology, 2003
Post-prostatectomy urinary incontinence is an uncommon complication of adenomectomies, occurring in approximately 1% of cases and being more frequent following radical prostatectomies.
Luis A.S. Rios, Rodrigo T. Tonin, Renato Panhoca, Osmar E.R. de Souza, Limírio L. da Fonseca Filho, Demerval Mattos Jr.   +5 more
doaj   +1 more source

Empiricism in artificial life

, 2004
Strong artificial life research is often thought to rely on Alife systems as sources of novel empirical data. It is hoped that by augmenting our observations of natural life, this novel data can help settle empirical questions, and thereby separate ...
Bullock, Seth, Silverman, Eric
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Study on post-traumatic stress disorder and influencing factors in adult ICU patients on mechanical ventilation using latent profile analysis: a cross-sectional survey

Frontiers in Psychology
ObjectiveThis study aimed to explore the potential classification and influencing factors of post-traumatic stress disorder (PTSD) in intensive care unit (ICU) patients receiving mechanical ventilation to provide a theoretical basis for formulating ...
Yunting Li, Xiaoli Yuan, Mi Liu, Yan Xiong, Jiabi Zhang   +4 more
doaj   +1 more source

Artificial States [PDF]

Artificial states are those in which political borders do not coincide with a division of nationalities desired by the people on the ground. We propose and compute for all countries in the world two new measures how artificial states are. One is based on
Alberto Alesina, Janina Matuszeski, William Easterly   +2 more
core   +1 more source