Results 91 to 100 of about 5,068,920 (347)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Biomimetic Hair Sensor Arrays: From Inspiration To Implementation [PDF]

, 2010
In this work, we report on the successful implementation of highly sensitive artificial hair-based flow-sensor arrays for sensing low-frequency air flows. Artificial hair sensors are bio-inspired from crickets’ cercal filiform hairs, one of nature’s best
Bruinink, C.M., Jaganatharaja, R.K., Kolster, M.L., Krijnen, G.J.M., Lammerink, T.S.J., Wiegerink, R.J.   +5 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Ethical and Statistical Considerations in Models of Moral Judgments

Frontiers in Robotics and AI, 2019
This work extends recent advancements in computational models of moral decision making by using mathematical and philosophical theory to suggest adaptations to state of the art.
Torty Sivill
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

EFEITOS DO TREINAMENTO MUSCULAR ESQUELÉTICO EM PACIENTES SUBMETIDOS À VENTILAÇÃO MECÂNICA PROLONGADA

Cogitare Enfermagem, 2010
Estudo com o objetivo de relatar os efeitos da aplicação do treinamento muscular esquelético em dois pacientesinternados em unidade de terapia intensiva. Foram realizadas avaliações na internação; no desmame do ventilador mecânico;na alta da unidade e na
Aenir Irena Borges Pedroso, Marciéli Bigolin, Marisa Pereira Gonçalves, Roberta Weber Werle   +3 more
doaj   +1 more source

Artificialities: From Artificial Intelligence to Artificial Culture

, 2006
Artificialities: From Artificial Intelligence to Artificial Culture Subjectivity, Embodiment and Technology in Contemporary Speculative Texts This thesis is an examination of the articulation, construction and representation of ‘the artificial’ in contemporary speculative texts in relation to notions of identity, subjectivity and embodiment ...
openaire   +1 more source

Observation of Light Guiding by Artificial Gauge Fields

, 2018
The use of artificial gauge fields enables systems of uncharged particles to behave as if affected by external fields. Generated by geometry or external modulation, artificial gauge fields have been instrumental in demonstrating topological phenomena in ...
Bandres, Miguel A., Heinrich, Matthias, Herzig-Sheinfux, Hanan, Lumer, Yaakov, Maczewsky, Lukas, Segev, Mordechai, Szameit, Alexander   +6 more
core   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source