Results 31 to 40 of about 1,801,177 (317)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Comportamento funcional dos portadores de marcapasso convencional submetidos a ressincronização cardíaca Functional behavior of patients with conventional pacemakers undergoing cardiac resynchronization

Arquivos Brasileiros de Cardiologia, 2008
FUNDAMENTO: A terapia de ressincronização cardíaca (TRC) é eficiente no tratamento de pacientes com insuficiência cardíaca (IC), disfunção ventricular grave e bloqueio intraventricular.
Rodrigo Tavares Silva, Martino Martinelli Filho, Carlos Eduardo Batista de Lima, Daniela Garcia Moreno Cabral Martins, Silvana Angelina Dorio Nishióka, Anísio Alexandre Pedrosa, Elizabeth Sartori Crevelari, Roberto Costa, Eduardo Argentino Sosa, José Antonio Franchini Ramires   +9 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Injectable Bulking Agents for Urinary Incontinence after Radical Prostatectomy, Mimicking Local Recurrence: A Case Report

대한영상의학회지, 2017
Periurethral bulking agent injection (or transurethral submucosal injection) is a comparatively less invasive procedure for the treatment of stress urinary incontinence in patients who develop incontinence after radical prostatectomy, and who are more ...
Jehong Yoon, Sung Eun Ahn, Sung Kyoung Moon, Seong Jin Park, Joo Won Lim, Sun Ju Lee   +5 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Atrial Standstill: a Rare Case

Journal of Tehran University Heart Center, 2011
We introduce a 32-year-old man who was evaluated for a dizziness and headache of unknown origin for at least two months and was referred to our center after ECG findings.
Ahmad Yaminisharif, Akbar Shafiee, Mohammad Sahebjam, Ali Moezzi   +3 more
doaj  

Estimulação cardíaca artificial em pacientes portadores de cardiomiopatia hipertrófica: uma coorte com 24 anos de seguimento Cardiac pacing in hypertrophic cardiomyopathy: a cohort with 24 years of follow-up

Arquivos Brasileiros de Cardiologia, 2008
FUNDAMENTO: O benefício da estimulação cardíaca em pacientes portadores de cardiomiopatia hipertrófica (CMH) tem sido questionado, sendo escassas as pesquisas sobre este assunto no Brasil.
Lenine Angelo Alves Silva, Edmundo Arteaga Fernández, Martino Martinelli Filho, Roberto Costa, Sérgio Siqueira, Barbara Maria Ianni, Charles Mady   +6 more
doaj   +1 more source

Optimizing endoscopic ultrasound guided fine needle aspiration through artificial intelligence [PDF]

, 2023
Lai Mun Wang, Tiing Leong Ang
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Metaphysics of Design

DIID
The paper is concerned with beginning to lay a basis for a more comprehensive model of designing, one that can overcome the abyss between the conceptual limitations of purely professional designing and wider instincts of design capabilities.
Clive Dilnot
doaj   +1 more source