Results 171 to 180 of about 29,894 (225)

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville, Ryan F. Yoshimura, Hanh A. Nguyen, Ruiming Zhao, Derk J. Hogenkamp, Steve A. N. Goldstein, Geoffrey W. Abbott   +6 more
wiley   +1 more source

Mechanomedicine. [PDF]

Nat Rev Bioeng
Liu Z, Chen G, Jo MS, Vogel V, Chen J, Rogers JA, Li S.   +6 more
europepmc   +1 more source

Co‐Culture of Mammalian Cells and Photosynthetic Microorganisms for Oxygen Supply in Engineered Tissues

Cell Proliferation, EarlyView.
Continuous 28‐day light exposure alters behaviours of articular cartilage progenitor cells (ACPCs) and mesenchymal stromal cells (MSCs). Co‐culture with Leptolyngbya and Synechococcus does not adversely affect the chondrogenic capacity of ACPCs over a 28‐day period, in contrast to co‐culture with Chlorella.
Meng Wang, Ahmad Furqan Hala, Vera van der Niet, Sebastian T. Bok, Aylin Kara Özenler, Marcel Janssen, Maria J. Barbosa, Dirk Martens, Rene H. Wijffels, Jos Malda, Mylène de Ruijter   +10 more
wiley   +1 more source

Artificial Intelligence-Guided Neuromodulation in Heart Failure with Preserved and Reduced Ejection Fraction: Mechanisms, Evidence, and Future Directions. [PDF]

J Cardiovasc Dev Dis
Ansari RA, Senapati SG, Ahluwalia V, Panjwani GAR, Kaur A, Yerrapragada G, Jayapradhaban Kala J, Elangovan P, Karuppiah SS, Asadimanesh N, Muthyala A, Arunachalam SP.   +11 more
europepmc   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Flexible bioelectronic sensors promote the advancement of wearable ultrasound technology in the medicine. [PDF]

Microsyst Nanoeng
Li J, Li G, Ma C, Li W, Yu G, Xiang L, Yao G.   +6 more
europepmc   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Acute heart failure physiology reversed by endoscopic removal of retained toothbrushes in gastro-cardiac (Roemheld) syndrome: a case report. [PDF]

Eur Heart J Case Rep
Jurin I, Poljak TBD, Bulum A, Paštrović F.   +3 more
europepmc   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, EarlyView.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Case Report: rTMS for recurrent major depressive disorder and generalized anxiety disorder comorbid with atrial fibrillation. [PDF]

Front Psychiatry
Reddy V, Frutkin N, Singh A, Pappu M, Raval K, Odron M, Vigilia C, Blum K, Baron D, Sunder K.   +9 more
europepmc   +1 more source