Results 161 to 170 of about 29,894 (225)

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Neuromodulation using Bioelectronics-enabled therapies to combat insulin resistance and its comorbidities. [PDF]

J Diabetes Metab Disord
Mekki YM, Park J, Alzaareer Z, Hussain Z, Gulzar A, Elzouki A, Güemes A, Zughaier SM.   +7 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Spontaneous Conception During Ovarian Stimulation Complicated by Severe Ovarian Hyperstimulation Syndrome (OHSS) With Atypical β-Human Chorionic Gonadotropin (β-hCG) Trends: A Case Report. [PDF]

Cureus
Nahouli L, Chamseddine N, Alameddine O, Aouad G, Ghazeeri G.   +4 more
europepmc   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Artificial intelligence-driven design and optimization of mitochondria-targeted nanocarriers for chronic heart failure. [PDF]

Front Bioeng Biotechnol
Zhang Z, Zhou X, Wei T, Meng L, Long K.
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Current trends in virtual electrophysiology use for risk stratification and treatment of ventricular arrhythmias. [PDF]

Front Cardiovasc Med
Antoniou CK, Karampinos K, Tsiachris D, Kordalis A, Arsenos P, Doundoulakis I, Dilaveris P, Milaras N, Sideris S, Kariki O, Kasiakogias A, Vlachopoulos C, Toutouzas K, Tsioufis K, Gatzoulis K.   +14 more
europepmc   +1 more source

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu, Lisa Zimmer, Dimitra Vlachopoulou, Elias Haj‐Yehia, Julia Hoffmann, Lars Michel, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Matthias Totzeck, Tienush Rassaf   +10 more
wiley   +1 more source

Materials and System Design for Self-Decision Bioelectronic Systems. [PDF]

Adv Mater
Zeng Q, Liu H, Zhang Y, Zheng Y, Ding X, Zhu M, Shi G, Wang Y, Haick H, Zhang M.   +9 more
europepmc   +1 more source