Results 71 to 80 of about 333,315 (344)

Silkworm Pupae Function as Efficient Producers of Recombinant Glycoproteins with Stable-Isotope Labeling

open access: yesBiomolecules, 2020
Baculovirus-infected silkworms are promising bioreactors for producing recombinant glycoproteins, including antibodies. Previously, we developed a method for isotope labeling of glycoproteins for nuclear magnetic resonance (NMR) studies using silkworm ...
Hirokazu Yagi   +9 more
doaj   +1 more source

Development of Digestive Enzymes Activity on Black Saddled Coral Grouper (Plectropomus Laevis) Larvae [PDF]

open access: yes, 2016
Protease, amylase, and lipase enzymes were used as biological indicators to measure larvae's food digestion. The aim of this study was to describe digestive enzyme activity development of black saddled coral grouper (Plectropomus laevis) larvae. The just
Aslianti, T. (Titiek), Slamet, B. (Bejo)
core   +3 more sources

Multitasking Smart Intestinal Capsule Robot: A Cutting‐Edge Platform for Sampling, Diagnosis, and Therapy

open access: yesAdvanced Robotics Research, EarlyView.
Gut microbiota and biomarkers are linked to diseases like neurological disorders and metabolic syndromes. Ingestible capsule robots enable minimally invasive gut health assessment. This article proposes a promising direction for the advancement of capsule robots, integrating in situ sampling, real‐time diagnostics, and personalized therapy.
Xizong Chen   +3 more
wiley   +1 more source

Comportamento alimentar e qualidade da água em tanques de criação de girinos de rã-touro Lithobates catesbeianus = Feeding behavior and water quality in tanks containing bullfrog tadpoles Lithobates catesbeianus

open access: yesActa Scientiarum: Animal Sciences, 2008
O objetivo deste trabalho foi avaliar o comportamento alimentar e a qualidade da água em tanques de criação de girinos de rã-touro Lithobates catesbeianus durante 56 dias, a partir do estágio 25 da Tabela de Gosner (1960), criados em tanques de alvenaria
Lúcia Helena Sipaúba-Tavares   +2 more
doaj  

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

open access: yesAdvanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva   +28 more
wiley   +1 more source

Olfaction scaffolds the developing human from neonate to adolescent and beyond [PDF]

open access: yes, 2020
The impact of the olfactory sense is regularly apparent across development. The foetus is bathed in amniotic fluid that conveys the mother’s chemical ecology.
Durand, Karine   +4 more
core   +3 more sources

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

open access: yesAdvanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai   +13 more
wiley   +1 more source

Analysis of the reproductive viability of Varroa destructor (Mesostigmata: Varroidae) rearing under laboratory conditions

open access: yesPersian Journal of Acarology
The Varroa destructor Anderson & Trueman, 2000 (Mesostigmata: Varroidae) is one of the most detrimental pests for the physiology and productivity of Apis mellifera (Hymenoptera: Apidae) in the international context.
Jesús Humberto Reyna-Fuentes   +4 more
doaj   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

open access: yesAdvanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu   +13 more
wiley   +1 more source

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

open access: yesAdvanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou   +14 more
wiley   +1 more source

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