Results 101 to 110 of about 246,202 (334)

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

open access: yesAdvanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang   +15 more
wiley   +1 more source

Exploring the proficiency of ChatGPT-4: An evaluation of its performance in the Taiwan advanced medical licensing examination

open access: yesDigital Health
Background Taiwan is well-known for its quality healthcare system. The country's medical licensing exams offer a way to evaluate ChatGPT's medical proficiency.
Shih-Yi Lin   +3 more
doaj   +1 more source

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

open access: yesAdvanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun   +12 more
wiley   +1 more source

Improved CKD classification based on explainable artificial intelligence with extra trees and BBFS

open access: yesScientific Reports
Chronic kidney disease is a persistent ailment marked by the gradual decline of kidney function. Its classification primarily relies on the estimated glomerular filtration rate and the existence of kidney damage.
Ahmed M. Elshewey   +2 more
doaj   +1 more source

Transplantology of the 21st century: High technologies in medicine and innovations in biomedical science

open access: yesВестник трансплантологии и искусственных органов, 2017
Review of the main research areas and the most significant results obtained in recent years in the Federal Research Center of Transplantology and Artificial Organs including heart transplantation, lung transplantation, the evolution of liver ...
S. V. Gautier
doaj   +1 more source

Artificial Intelligence in Kidney Transplantation: A Scoping Review (Preprint)

open access: gold, 2021
Mowafa Househ   +3 more
openalex   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang   +18 more
wiley   +1 more source

Active Osmotic Exchanger for Efficient Nanofiltration Inspired by the Kidney

open access: yesPhysical Review X, 2016
In this paper, we investigate the physical mechanisms underlying one of the most efficient filtration devices: the kidney. Building on a minimal model of the Henle loop—the central part of the kidney filtration—we investigate theoretically the detailed ...
Sophie Marbach, Lydéric Bocquet
doaj   +1 more source

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