Results 91 to 100 of about 8,673,646 (306)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
AN INDIVIDUAL-BASED MODEL OF SELF-REPRODUCTION SYSTEM
TASK Quarterly, 2001 The paper presents results of a few preliminary simulation experiments of a self-reproduction system realized in a programming environment for individual-based modelling of physical systems and discusses the advantages and difficulties of such modelling.
WOJCIECH JĘDRUCH, MARCIN GRAMZA
doaj
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Chemical Systems for Wetware Artificial Life: Selected Perspectives in Synthetic Cell Research. [PDF]
Int J Mol Sci, 2023 Stano P.
europepmc +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
A Wetware Embodied AI? Towards an Autopoietic Organizational Approach Grounded in Synthetic Biology
Frontiers in Bioengineering and Biotechnology, 2021 Luisa Damiano, Pasquale Stano
doaj +1 more source
Alife in the Clouds: A Short Review of Applications of Artificial Life to Cloud Computing and Back
Frontiers in Robotics and AI, 2018 Cloud computing is currently the prevailing mode of designing, creating, and deploying complex applications, and it has implied a paradigm shift in all three areas; even if it taps and extends previous concepts such as service oriented, concurrent, and ...
Juan-Julián Merelo-Guervós +4 more
doaj +1 more source
Synthetic Biology: Old and New Dilemmas-The Case of Artificial Life. [PDF]
BioTech (Basel), 2021 Kolisis N, Kolisis F.
europepmc +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source