Results 1 to 10 of about 467,673 (359)

Synthetic biology-inspired development of live attenuated influenza vaccines

npj Vaccines
Live attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns.
Qisi Zhang, Jiahui Cheng, Jihuan Hou, Yinlei Su, Le Li, Le Tong, Jing Li, Quan Shen, Zihao Wang, Minqi Wu, Zhen Li, Qikai Wang, Yunfei Zhang, Rui Sun, Longlong Si   +14 more
doaj   +1 more source

A transient mutational burst occurs during yeast colony development

Molecular Systems Biology
Characterizing the contribution of mutators to mutation accumulation is essential for understanding cellular adaptation and diseases like cancer. By measuring single and double mutation rates, including point mutations, segmental duplications, and ...
Nicolas Agier, Nina Vittorelli, Louis Ollivier, Frédéric Chaux, Alexandre Gillet-Markowska, Samuel O’Donnell, Fanny Pouyet, Gilles Fischer, Stéphane Delmas   +8 more
doaj   +1 more source

Publisher Correction: Encryption and steganography of synthetic gene circuits

Nature Communications, 2019
The original version of this Article contained an error in Fig. 4. In the lower part of the three gene circuit diagrams in panel b, the flat-headed arrow linking lambdaCI to the tetR promoter incorrectly pointed to the tetR gene body.
Oliver Purcell, Jerry Wang, Piro Siuti, Timothy K. Lu   +3 more
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A noncanonical role of roX RNAs in autosomal epigenetic repression

Nature Communications
Long noncoding RNAs known as roX (RNA on the X) are crucial for male development in Drosophila, as their loss leads to male lethality from the late larval stages.
Jianjian Li, Shuyang Xu, Zicong Liu, Liuyi Yang, Zhe Ming, Rui Zhang, Wenjuan Zhao, Huipai Peng, Jeffrey J. Quinn, Manyin Wu, Yushan Geng, Yuying Zhang, Jiazhi He, Minghai Chen, Nan Li, Ning-Yi Shao, Qing Ma   +16 more
doaj   +1 more source

Inducible chromosomal rearrangement reveals nonlinear polygenic dosage effects in driving aneuploid yeast traits

Nature Communications
Aneuploidy induces chromosomal scale alterations in gene dosage, impacting organismal proliferation yet serving as a driver for adaptive evolution.
Hongyi Yin, Zhou Guo, Chu Zhou, Lu Ma, Yi Wu, Ying-jin Yuan   +5 more
doaj   +1 more source

Exosome-Mediated Chemoresistance in Cancers: Mechanisms, Therapeutic Implications, and Future Directions

Biomolecules
Chemotherapy resistance represents a formidable obstacle in oncological therapeutics, substantially compromising the efficacy of adjuvant chemotherapy regimens and contributing to unfavorable clinical prognoses.
Gengqi Liu, Jingang Liu, Silu Li, Yumiao Zhang, Ren He   +4 more
doaj   +1 more source

Synthetic developmental biology: Engineering approaches to guide multicellular organization [PDF]

, 2022
Ibrahim Zarkesh, Mohammad Kazemi Ashtiani, Zahra Shiri, Saeideh Aran, Thomas Braun, Hossein Baharvand   +5 more
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Encryption and steganography of synthetic gene circuits

Nature Communications, 2018
Artificial gene circuits represent intellectual property that under some circumstances may need to be obfuscated to prevent discovery by third parties. Here the authors use encryption by overlapping recombinase sites and steganography by the introduction
Oliver Purcell, Jerry Wang, Piro Siuti, Timothy K. Lu   +3 more
doaj   +1 more source

Synthetic Biology-derived triterpenes as efficacious immunomodulating adjuvants [PDF]

, 2020
Mizuki Tateno, Barbara J. Stone, Sarah Srodulski, Stephanie E. Reedy, Thomas R. Gawriluk, Thomas M. Chambers, Jerold G. Woodward, Joe Chappell, Chase F. Kempinski   +8 more
openalex   +1 more source

Generation of an autophagy-targeting influenza A virus as live attenuated vaccine

Nature Communications
Despite existing vaccines, influenza remains a significant public health burden, highlighting the need for vaccine strategies with improved safety and efficacy. Here we develop an autophagy-targeting influenza.
Jiawei Hao, Ping Wang, Le Li, Qikai Wang, Quan Shen, Le Tong, Chengyao Liu, Zihao Wang, Qisi Zhang, Demin Zhou, Xiaoshan Shi, Longlong Si   +11 more
doaj   +1 more source