Synthetic biology: advancing biological frontiers by building synthetic systems [PDF]
, 2012 Advances in synthetic biology are contributing to diverse research areas, from basic biology to biomanufacturing and disease therapy.
Chen, Yvonne Y. +2 more
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Bottom-up assembly of functional intracellular synthetic organelles by droplet-based microfluidics
, 2020 Bottom-up synthetic biology has directed most efforts toward the construction of artificial compartmentalized systems that recreate living cell functions in their mechanical, morphological, or metabolic characteristics.
Platzman, I. +3 more
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Engineering orthogonal dual transcription factors for multi-input synthetic promoters [PDF]
, 2016 Synthetic biology has seen an explosive growth in the capability of engineering artificial gene circuits from transcription factors (TFs), particularly in bacteria. However, most artificial networks still employ the same core set of TFs (for example LacI,
Broedel, AK, Isalan, M, Jaramillo, A
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Synthetic Genomes for Synthetic Biology [PDF]
Journal of Molecular Cell Biology, 2010 A genome synthesized entirely from scratch has been used to replace the native genome of a living cell, thus creating a new cell. This achievement marks a new frontier in synthetic biology to design and create genomes for organisms with few genetic tools and for applications in areas of energy, health care and the environment.
openaire +2 more sources
A synthetic microbial biosensor for high-throughput screening of lactam biocatalysts
Nature Communications, 2018 Efficient biosynthesis of lactams is still undesirable due to lacking of suitable enzyme. Here, the authors develop a sensitive transcription factor-based biosensor for high-throughput screening of marine metagenome and find a cyclase that can cyclize ω ...
Soo-Jin Yeom +10 more
doaj +1 more source
Genomics and synthetic biology as a viable option to intensify sustainable use of biodiversity [PDF]
, 2011 The Amazon basin is an area of mega-biodiversity. Different models have been proposed^1-8^ for the establishment of an effective conservation policy, increasing sustainability and adding value for biodiversity. Currently, a broad spectrum of technologies
Elibio L. Rech
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Molecular and biochemical characterization of a novel isoprene synthase from Metrosideros polymorpha
BMC Plant Biology, 2018 Background Isoprene is a five-carbon chemical that is an important starting material for the synthesis of rubber, elastomers, and medicines. Although many plants produce huge amounts of isoprene, it is very difficult to obtain isoprene directly from ...
Soo-Jin Yeom +8 more
doaj +1 more source
Synthetic biology, engineering biology, market expectation
Engineering Biology, 2020 ‘Engineering biology’ is being increasingly adopted as a term by organisations that seek to deliver benefits from ‘synthetic biology’. However, are ‘engineering biology’ and ‘synthetic biology’ different words with the same meaning or do they signal ...
Lionel Clarke
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Inducible expression of large gRNA arrays for multiplexed CRISPRai applications
Nature Communications, 2022 CRISPR gene activation and inhibition has become a powerful synthetic tool for influencing the expression of native genes for foundational studies, cellular reprograming, and metabolic engineering.
William M. Shaw +7 more
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Synthetic biology: biology by design [PDF]
Microbiology, 2013 Synthetic biology can be defined as the design and construction of novel biologically based parts, devices and systems, as well as the redesign of existing natural biological systems, for useful purposes. It builds on genetic engineering, being design-driven genetic engineering encompassing engineering concepts of standardization and abstraction (Endy,
Roberts, MAJ +3 more
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