Results 41 to 50 of about 427,199 (265)
Nature CommunicationsMicrobial physiology plays a pivotal role in construction of superior microbial cell factories for efficient biosynthesis of desired products. Here we identify that pcnB repression confers improved physiology for overproduction of free fatty acids (FFAs)
Lixia Fang +8 more
doaj +1 more source
Engineering consortia by polymeric microbial swarmbots
Nature Communications, 2022 Most attempts to co-cultivate the artificial microbial communities fail mostly due to the mismatched rates of consumption and production of nutrients among subpopulations. Here, the authors develop a microbial swarmbot mediated spatial segregation method
Lin Wang +15 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast
Nature Communications, 2017 Filamentous fungi are a valuable source of natural therapeutic products such as antibiotics. Here the authors engineer monocellularS. cerevisiaeto perform complex secondary metabolism typical of multicellular fungi in order to demonstrate biosynthesis ...
Ali R. Awan +6 more
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Microbial Cell Factories, 2022 The inclusion of biosafety strategies into strain engineering pipelines is crucial for safe-by-design biobased processes. This in turn might enable a more rapid regulatory acceptance of bioengineered organisms in both industrial and environmental ...
Enrique Asin-Garcia +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
All-in-One photo-biocatalysis system for sustainable chemical transformations
Nature CommunicationsEnzyme-photo-coupled systems (EPCSs) offer a green strategy for producing high-value chemicals, but significant gaps remain in comparison to natural photosynthetic systems.
Si Liu, Siyao Zhang, Yan Sun
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Self-healing unmanned aerial vehicle skin for icing prevention and intelligent monitoring
npj Flexible ElectronicsIn-flight icing is a common hazard in unmanned aerial vehicles (UAVs), accounting for 25% of drone accidents due to their sensitivity to weight increase.
Sijia Xu +7 more
doaj +1 more source