Results 41 to 50 of about 2,683,742 (306)
Synthetic biology for synthetic chemistry
New Biotechnology, 2008 The richness and versatility of biological systems make them ideally suited to solve some of the world's most significant challenges, such as converting cheap, renewable resources into energy-rich molecules; producing high-quality, inexpensive drugs to fight disease; and remediating polluted sites.
openaire +2 more sources
Varieties of Noise: Analogical Reasoning in Synthetic Biology [PDF]
, 2013 The picture of synthetic biology as a kind of engineering science has largely created the public understanding of this novel field, covering both its promises and risks.
Knuuttila, Tarja, Loettgers, Andrea
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Nature CommunicationsThe site-specific recombination system is a versatile tool in genome engineering, enabling controlled DNA inversion or deletion at specific sites to generate genetic diversity.
Jieyi Li +12 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Rank-guided learning accelerates automated enzyme engineering
Nature CommunicationsEnzyme catalysis has become a cornerstone of modern synthesis, offering sustainable routes to structurally complex molecules. However, the rugged fitness landscape and limited model capacity to learn from sparse data constrain the development of ...
Jingyi Xu +5 more
doaj +1 more source
Can synthetic biology shed light on the origin of life? [PDF]
, 2009 It is a most commonly accepted hypothesis that life originated from inanimate matter, somehow being a synthetic product of organic aggregates, and as such, a result of some sort of prebiotic synthetic biology.
Malaterre, Christophe
core
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Construction of microbial systems for polyethylene terephthalate degradation
Synthetic and Systems BiotechnologyPolyethylene terephthalate (PET) is one of the most widely used plastic materials, and its large-scale application has caused severe environmental pollution.
Dingkun He +3 more
doaj +1 more source
Engineering Biology, 2019 Clostridium autoethanogenum is an industrial microbe used for the commercial-scale production of ethanol from carbon monoxide. While significant progress has been made in the attempted diversification of this bioprocess, further improvements are ...
Rupert O.J. Norman +13 more
doaj +1 more source