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Editorial–Synthetic Biology [PDF]

Nucleic Acids Research, 2010
Synthetic biology builds upon over 35 years of genetic engineering. For example, in the 1970s methods were invented for using enzymes to rework DNA. Applying these tools, bacteria were engineered to yield relevant products such as growth hormones and insulin.
Collins, James J., Endy, Drew, Hutchison, Clyde A., Roberts, Richard J.   +3 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Drop-in biofuel production using fatty acid photodecarboxylase from Chlorella variabilis in the oleaginous yeast Yarrowia lipolytica

Biotechnology for Biofuels, 2019
Background Oleaginous yeasts are potent hosts for the renewable production of lipids and harbor great potential for derived products, such as biofuels.
Stefan Bruder, Eva Johanna Moldenhauer, Robert Denis Lemke, Rodrigo Ledesma-Amaro, Johannes Kabisch   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Bioactivities and biosynthesis of monoterpene-based biopesticides: current state and perspectives

Microbial Cell Factories
Biopesticides constitute a category of natural products and organisms effective against pests. Given their advantages, such as easier clearance and degradation compared to chemical pesticides, along with their lack of detrimental effects on ecosystem ...
Ruiqi Chen, Weilin Liu, Daoguang Tian, Shengli Wang, Jianjun Qiao, Weiguo Li, Qinggele Caiyin   +6 more
doaj   +1 more source

Regulating protein glycosylation modification enhances the synthesis of taxadiene in Saccharomyces cerevisiae

Synthetic and Systems Biotechnology
Utilizing synthetic biology techniques to construct recombinant engineered cells for the synthesis of paclitaxel and its key precursors has emerged as an effective method to address the supply–demand imbalance and protect rare plant resources. Taxadiene,
Chenglong Zhang, Jia Wang, Longfei Zhao, Nan Wu, Yi Shi, Xia Li, Changqiang Ke, Jia Liu, Yang Ye, Ying Wang, Bingzhi Li, Wenhai Xiao, Mingdong Yao, Yingjin Yuan   +13 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Carbon Dot Self‐Assembly: Bottom‐Up Fabrication, Morphological Evolution, Luminescence Regulation, and Advanced Applications

Aggregate
Carbon dots (CDs) have garnered widespread interest in biosensing, optoelectronics, and biomedicine due to their exceptional fluorescence, biocompatibility, and low cost.
Kai Chen, Zhi‐Min Zhao, Zhi‐Hua Liu, Li Xu, Junbo Gong, Bing‐Zhi Li   +5 more
doaj   +1 more source