Results 71 to 80 of about 934,952 (299)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Increasing cellular fitness and product yields in Pseudomonas putida through an engineered phosphoketolase shunt

Microbial Cell Factories, 2023
Background Pseudomonas putida has received increasing interest as a cell factory due to its remarkable features such as fast growth, a versatile and robust metabolism, an extensive genetic toolbox and its high tolerance to oxidative stress and toxic ...
Lyon Bruinsma, Maria Martin-Pascual, Kesi Kurnia, Marieken Tack, Simon Hendriks, Richard van Kranenburg, Vitor A. P. Martins dos Santos   +6 more
doaj   +1 more source

Making serine integrases work for us [PDF]

, 2017
DNA site-specific recombinases are enzymes (often associated with mobile DNA elements) that catalyse breaking and rejoining of DNA strands at specific points, thereby bringing about precise genetic rearrangements.
Stark, W. Marshall
core   +1 more source

Synthetic biology, inspired by synthetic chemistry

FEBS Letters, 2012
We like to give an overview about the developments in the field of synthetic biology, regarding polymer‐based analogs of cellular membranes and what questions can be answered by applying synthetic polymer science towards the smallest unit in life, namely a cell.
Malinova, V., Nallani, M., Meier, W. P., Sinner, E. K.   +3 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Regulating protein glycosylation modification enhances the synthesis of taxadiene in Saccharomyces cerevisiae

Synthetic and Systems Biotechnology
Utilizing synthetic biology techniques to construct recombinant engineered cells for the synthesis of paclitaxel and its key precursors has emerged as an effective method to address the supply–demand imbalance and protect rare plant resources. Taxadiene,
Chenglong Zhang, Jia Wang, Longfei Zhao, Nan Wu, Yi Shi, Xia Li, Changqiang Ke, Jia Liu, Yang Ye, Ying Wang, Bingzhi Li, Wenhai Xiao, Mingdong Yao, Yingjin Yuan   +13 more
doaj   +1 more source

Coiled-coil heterodimers with increased stability for cellular regulation and sensing SARS-CoV-2 spike protein-mediated cell fusion

Scientific Reports, 2021
Coiled-coil (CC) dimer-forming peptides are attractive designable modules for mediating protein association. Highly stable CCs are desired for biological activity regulation and assay.
Tjaša Plaper, Jana Aupič, Petra Dekleva, Fabio Lapenta, Mateja Manček Keber, Roman Jerala, Mojca Benčina   +6 more
doaj   +1 more source

Sustainability and Anticipatory Governance in Synthetic Biology [PDF]

, 2012
A prominent imaginary of synthetic biology is the sustainability of bio-based technologies. In this paper, the authors discuss various reports, papers, and activities in synthetic biology in relation to a core set of principles of sustainability, paying ...
A.Wiek, D.Barben, D.Sarewitz, G. E.Marcus, M. A.Bedau, P.Chopra, R. K.Turner   +6 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Bioactivities and biosynthesis of monoterpene-based biopesticides: current state and perspectives

Microbial Cell Factories
Biopesticides constitute a category of natural products and organisms effective against pests. Given their advantages, such as easier clearance and degradation compared to chemical pesticides, along with their lack of detrimental effects on ecosystem ...
Ruiqi Chen, Weilin Liu, Daoguang Tian, Shengli Wang, Jianjun Qiao, Weiguo Li, Qinggele Caiyin   +6 more
doaj   +1 more source