Results 91 to 100 of about 3,570,847 (308)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
A Synthetic Post-transcriptional Controller To Explore the Modular Design of Gene Circuits [PDF]
, 2012 The assembly from modular parts is an efficient approach for creating new devices in Synthetic Biology. In the “bottom-up” designing strategy, modular parts are characterized in advance, and then mathematical modeling is used to predict the outcome of ...
Ceroni, Francesca +10 more
core +1 more source
AggregateCarbon dots (CDs) have garnered widespread interest in biosensing, optoelectronics, and biomedicine due to their exceptional fluorescence, biocompatibility, and low cost.
Kai Chen +5 more
doaj +1 more source
Synthetic and Systems BiotechnologyUtilizing synthetic biology techniques to construct recombinant engineered cells for the synthesis of paclitaxel and its key precursors has emerged as an effective method to address the supply–demand imbalance and protect rare plant resources. Taxadiene,
Chenglong Zhang +13 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Plant BiotechnologySynthetic biology, an interdisciplinary field at the intersection of engineering and biology, has garnered considerable attention for its potential applications in plant science. By exploiting engineering principles, synthetic biology enables the redesign and construction of biological systems to manipulate plant traits, metabolic pathways, and ...
Hayakawa, Takahiko +3 more
openaire +2 more sources
Bioactivities and biosynthesis of monoterpene-based biopesticides: current state and perspectives
Microbial Cell FactoriesBiopesticides constitute a category of natural products and organisms effective against pests. Given their advantages, such as easier clearance and degradation compared to chemical pesticides, along with their lack of detrimental effects on ecosystem ...
Ruiqi Chen +6 more
doaj +1 more source
Biotechnology for Biofuels, 2019 Background Oleaginous yeasts are potent hosts for the renewable production of lipids and harbor great potential for derived products, such as biofuels.
Stefan Bruder +4 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source