Results 91 to 100 of about 2,683,742 (306)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Mathematical modelling and non-linear analysis of Synthetic Gene Regulatory Networks [PDF]

, 2010
The emerging discipline of Synthetic biology can be defined as the engineering of biology. The usefulness of a model in Synthetic biology lies in its ability to formalise the knowledge about the biological process at hand, to identify inconsistencies ...
Marucci, Lucia
core   +1 more source

Synthetic Lipid Biology

Chemical Reviews
Cells contain thousands of different lipids. Their rapid and redundant metabolism, dynamic movement, and many interactions with other biomolecules have justly earned lipids a reputation as a vexing class of molecules to understand. Further, as the cell's hydrophobic metabolites, lipids assemble into supramolecular structures─most commonly bilayers, or ...
Po-Hsun Brian Chen, Xiang-Ling Li, Jeremy M. Baskin   +2 more
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Carbon Dot Self‐Assembly: Bottom‐Up Fabrication, Morphological Evolution, Luminescence Regulation, and Advanced Applications

Aggregate
Carbon dots (CDs) have garnered widespread interest in biosensing, optoelectronics, and biomedicine due to their exceptional fluorescence, biocompatibility, and low cost.
Kai Chen, Zhi‐Min Zhao, Zhi‐Hua Liu, Li Xu, Junbo Gong, Bing‐Zhi Li   +5 more
doaj   +1 more source

Regulating protein glycosylation modification enhances the synthesis of taxadiene in Saccharomyces cerevisiae

Synthetic and Systems Biotechnology
Utilizing synthetic biology techniques to construct recombinant engineered cells for the synthesis of paclitaxel and its key precursors has emerged as an effective method to address the supply–demand imbalance and protect rare plant resources. Taxadiene,
Chenglong Zhang, Jia Wang, Longfei Zhao, Nan Wu, Yi Shi, Xia Li, Changqiang Ke, Jia Liu, Yang Ye, Ying Wang, Bingzhi Li, Wenhai Xiao, Mingdong Yao, Yingjin Yuan   +13 more
doaj   +1 more source

Aspects of the political economy of development and synthetic biology [PDF]

, 2009
What implications might synthetic biology’s potential as a wholly new method of production have for the world economy, particularly developing countries?
Wellhausen, Rachel, Rachel Wellhausen, Mukunda, Gautam, Gautam Mukunda   +3 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Bioactivities and biosynthesis of monoterpene-based biopesticides: current state and perspectives

Microbial Cell Factories
Biopesticides constitute a category of natural products and organisms effective against pests. Given their advantages, such as easier clearance and degradation compared to chemical pesticides, along with their lack of detrimental effects on ecosystem ...
Ruiqi Chen, Weilin Liu, Daoguang Tian, Shengli Wang, Jianjun Qiao, Weiguo Li, Qinggele Caiyin   +6 more
doaj   +1 more source

Drop-in biofuel production using fatty acid photodecarboxylase from Chlorella variabilis in the oleaginous yeast Yarrowia lipolytica

Biotechnology for Biofuels, 2019
Background Oleaginous yeasts are potent hosts for the renewable production of lipids and harbor great potential for derived products, such as biofuels.
Stefan Bruder, Eva Johanna Moldenhauer, Robert Denis Lemke, Rodrigo Ledesma-Amaro, Johannes Kabisch   +4 more
doaj   +1 more source