Results 81 to 90 of about 2,683,742 (306)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Synthetic Biology in the Press

, 2015
Synthetic biology is a rapidly evolving field which potentially can change how we live in and understand the world. Given its potential impact it is important to inform and involve the public so that it gains a proper understanding of synthetic biology ...
Stefan Eriksson, Eriksson, Stefan,, Mirko Ancillotti, Ancillotti, Mirko,   +3 more
core   +1 more source

Design and Reconstruction of Regulatory Parts for Fast-frowing Vibrio natriegens Synthetic Biology

, 2020
The fast-growing Vibrio natriegens is an attractive robust chassis for diverse synthetic biology applications. However, V. natriegens lacks the suitable constitutive regulatory parts for precisely tuning the gene expression and, thus, recapitulating ...
Tu, Ran, Lin, Yuping, Chen, Wujiu, Wu, Fengli, Wang, Qinhong, Peng, Yanfeng, Xing, Jianmin   +6 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Self-healing unmanned aerial vehicle skin for icing prevention and intelligent monitoring

npj Flexible Electronics
In-flight icing is a common hazard in unmanned aerial vehicles (UAVs), accounting for 25% of drone accidents due to their sensitivity to weight increase.
Sijia Xu, Ruiqi Li, Shu Tian, Junyu Yu, Chengtao An, Kai Yang, Jing Yang, Lei Zhang   +7 more
doaj   +1 more source

EcoFlex - a multifunctional MoClo kit for E. coli synthetic biology [PDF]

, 2016
Golden Gate cloning is a prominent DNA assembly tool in synthetic biology for the assembly of plasmid constructs often used in combinatorial pathway optimisation, with a number of assembly kits developed specifically for yeast and plant-based expression.
Chee, Soo Mei, Richard J. R. Kelwick (2631502), Bell, DJ, Polizzi, K, Paul S. Freemont (322767), Mei, S, Kelwick, R, Hung-En Lai (2631508), David J. Bell (85983), Freemont, PS, Bell, David J., Simon J. Moore (2631511), Freemont, Paul S., Karen Marie Polizzi (2631505), Polizzi, Karen Marie, Moore, Simon J., Lai, Hung-En, lai, H-E, Moore, SJ, Soo Mei Chee (2631514), Kelwick, Richard J. R.   +20 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Synthetic biology: Below the radar [Book review] [PDF]

, 2017
Englehard et al provide a wide-ranging look at synthetic biology, from discussion of how one might classify different synthetic approaches to consideration of risk and ethical issues. The chapter on public engagement considers why synthetic biology seems
Weitkamp, Emma
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Synthetic biology in plants

Plant Biotechnology
Synthetic biology, an interdisciplinary field at the intersection of engineering and biology, has garnered considerable attention for its potential applications in plant science. By exploiting engineering principles, synthetic biology enables the redesign and construction of biological systems to manipulate plant traits, metabolic pathways, and ...
Hayakawa, Takahiko, Suzuki, Hayato, Yamamoto, Hiroshi, Mitsuda, Nobutaka   +3 more
openaire   +2 more sources