Results 81 to 90 of about 934,952 (299)
Autopoiesis Concepts for Chemical Origins of Life and Synthetic Biology [Stenogram of the popular lecture on the foreign bibliographic seminar] [PDF]
, 2017 The monograph (Luisi P.L. "The Emergence of Life: From Chemical Origins to Synthetic Biology", 2010, Cambridge University Press, Cambridge, New York etc., 315 p.) is a well-written, informative book providing a novel view on the interrelation between the
Gradoff, Olle
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Publisher Correction: Encryption and steganography of synthetic gene circuits
Nature Communications, 2019 The original version of this Article contained an error in Fig. 4. In the lower part of the three gene circuit diagrams in panel b, the flat-headed arrow linking lambdaCI to the tetR promoter incorrectly pointed to the tetR gene body.
Oliver Purcell +3 more
doaj +1 more source
The Role of Synthetic Biology in NASA's Missions [PDF]
The time has come to for NASA to exploit the nascent field of synthetic biology in pursuit of its mission, including aeronautics, earth science, astrobiology and notably, human exploration.
Rothschild, Lynn J.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A transient mutational burst occurs during yeast colony development
Molecular Systems BiologyCharacterizing the contribution of mutators to mutation accumulation is essential for understanding cellular adaptation and diseases like cancer. By measuring single and double mutation rates, including point mutations, segmental duplications, and ...
Nicolas Agier +8 more
doaj +1 more source
Synthetic biology—putting engineering into biology [PDF]
, 2017 Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias, Panke, Sven
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A noncanonical role of roX RNAs in autosomal epigenetic repression
Nature CommunicationsLong noncoding RNAs known as roX (RNA on the X) are crucial for male development in Drosophila, as their loss leads to male lethality from the late larval stages.
Jianjian Li +16 more
doaj +1 more source