Results 61 to 70 of about 427,199 (265)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Synthetic biology-inspired development of live attenuated influenza vaccines
npj VaccinesLive attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns.
Qisi Zhang +14 more
doaj +1 more source
Publisher Correction: Encryption and steganography of synthetic gene circuits
Nature Communications, 2019 The original version of this Article contained an error in Fig. 4. In the lower part of the three gene circuit diagrams in panel b, the flat-headed arrow linking lambdaCI to the tetR promoter incorrectly pointed to the tetR gene body.
Oliver Purcell +3 more
doaj +1 more source
The economics of synthetic biology
Molecular Systems Biology, 2007 Mol Syst Biol. 3: 117 Ten years ago, genetic engineering was limited to cutting and pasting DNA from existing organisms. Today's biologists can write down gene sequences that have never existed anywhere, place an order over the Internet, and receive the desired DNA by return mail.
Henkel, Joachim, Maurer, Stephen M
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
A transient mutational burst occurs during yeast colony development
Molecular Systems BiologyCharacterizing the contribution of mutators to mutation accumulation is essential for understanding cellular adaptation and diseases like cancer. By measuring single and double mutation rates, including point mutations, segmental duplications, and ...
Nicolas Agier +8 more
doaj +1 more source
Plant BiotechnologySynthetic biology, an interdisciplinary field at the intersection of engineering and biology, has garnered considerable attention for its potential applications in plant science. By exploiting engineering principles, synthetic biology enables the redesign and construction of biological systems to manipulate plant traits, metabolic pathways, and ...
Hayakawa, Takahiko +3 more
openaire +2 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
A noncanonical role of roX RNAs in autosomal epigenetic repression
Nature CommunicationsLong noncoding RNAs known as roX (RNA on the X) are crucial for male development in Drosophila, as their loss leads to male lethality from the late larval stages.
Jianjian Li +16 more
doaj +1 more source
Models for synthetic biology [PDF]
BMC Systems Biology, 2007 Synthetic biological engineering is emerging from biology as a distinct discipline based on quantification. The technologies propelling synthetic biology are not new, nor is the concept of designing novel biological molecules. What is new is the emphasis on system behavior.
openaire +2 more sources