Results 61 to 70 of about 934,952 (299)
Nature CommunicationsMicrobial physiology plays a pivotal role in construction of superior microbial cell factories for efficient biosynthesis of desired products. Here we identify that pcnB repression confers improved physiology for overproduction of free fatty acids (FFAs)
Lixia Fang +8 more
doaj +1 more source
Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast
Nature Communications, 2017 Filamentous fungi are a valuable source of natural therapeutic products such as antibiotics. Here the authors engineer monocellularS. cerevisiaeto perform complex secondary metabolism typical of multicellular fungi in order to demonstrate biosynthesis ...
Ali R. Awan +6 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Misconceptions of Synthetic Biology: Lessons from an Interdisciplinary Summer School [PDF]
, 2016 In 2014, an international group of scholars from various fields analysed the "societal dimensions" of synthetic biology in an interdisciplinary summer school. Here, we report and discuss the biologists' observations on the general perception of synthetic
Acevedo-Rocha, Carlos G. +3 more
core +2 more sources
Nano‐enabled synthetic biology
Molecular Systems Biology, 2007 Biological systems display a functional diversity, density and efficiency that make them a paradigm for synthetic systems. In natural systems, the cell is the elemental unit and efforts to emulate cells, their components, and organization have relied primarily on the use of bioorganic materials.
Doktycz, Mitchel J, Simpson, Michael L
openaire +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Self-healing unmanned aerial vehicle skin for icing prevention and intelligent monitoring
npj Flexible ElectronicsIn-flight icing is a common hazard in unmanned aerial vehicles (UAVs), accounting for 25% of drone accidents due to their sensitivity to weight increase.
Sijia Xu +7 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Biotechnology for Biofuels, 2019 Background Oleaginous yeasts are potent hosts for the renewable production of lipids and harbor great potential for derived products, such as biofuels.
Stefan Bruder +4 more
doaj +1 more source
Design and Analysis of Genetically Constructed Logic Gates [PDF]
, 2014 Synthetic biology, comprising many aspects including in vivo, in vitro and in silico techniques, models and methods, programming paradigms and tools, is a rapidly growing field with promising potential in building new synthetically constructed devices ...
Gheorghe, M., Konur, S.
core +1 more source