Results 41 to 50 of about 440,950 (267)

Prediction Model of Wastewater Pollutant Indicators Based on Combined Normalized Codec

Mathematics, 2022
Effective prediction of wastewater treatment is beneficial for precise control of wastewater treatment processes. The nonlinearity of pollutant indicators such as chemical oxygen demand (COD) and total phosphorus (TP) makes the model difficult to fit and
Chun-Ming Xu, Jia-Shuai Zhang, Ling-Qiang Kong, Xue-Bo Jin, Jian-Lei Kong, Yu-Ting Bai, Ting-Li Su, Hui-Jun Ma, Prasun Chakrabarti   +8 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

THE LINK BETWEEN CIRCADIAN CLOCK AND TUMORIGENESIS

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2021
The circadian clock is fundamental for allowing the human body to work properly. Studies demonstrated that circadian disruption is a risk factor for a lot of pathological states and in this Review, the idea is to focus on tumorigenesis.
Arianna DANERI, ADRIAN LUPUȘOR, Ion MOLDOVANU, Victor VOVC   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Antimicrobial Peptide Screening from Microbial Genomes in Sludge Based on Deep Learning

Applied Sciences
As the issue of traditional antibiotic resistance continues to worsen, exploring new antimicrobial substances has become crucial to addressing this challenge. Antimicrobial peptides (AMPs), recognized for their low resistance levels and minimal bacterial
Yin-Xuan Liu, Xue-Bo Jin, Chun-Ming Xu, Hui-Jun Ma, Qi Wu, Hao-Si Liu, Zi-Meng Li   +6 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Growth and Yield Production of Pakcoy as Influenced by Artificial Light Irradiation

Journal of Applied Agricultural Science and Technology, 2023
Artificial light in indoor plant production is still a challenge related to the amount of electrical energy used, such as in the Pakcoy plant. The Pakcoy plant has nutritional and economic value and is usually used as a research indicator plant.
Sari Widya Utami, Artdhita Fajar Pratiwi, Galih Mustiko Aji   +2 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source