Results 41 to 50 of about 440,016 (267)

Light pollution affects the coastal zone of Lake Baikal

Limnological Review, 2021
The role of light pollution in aquatic ecosystems functioning has increased in recent times. In addition, the effect of such pollution has mostly been studied in coastal marine ecosystems, leaving freshwater ecosystems much less studied.
Karnaukhov Dmitry, Teplykh Maria, Dolinskaya Еkaterina, Biritskaya Sofya, Ermolaeva Yana, Pushnica Viktoria, Kuznetsova Iya, Okholina Anastasia, Bukhaeva Lidia, Silow Еugene   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Dynamic Cross-Modal Modeling with an Ultra-Lightweight Architecture for Face Anti-Spoofing

Sensors
The effectiveness of multimodal face anti-spoofing largely depends on the modeling of cross-modal relationships. However, most existing approaches rely on static fusion or implicitly learned feature aggregation, which assumes fixed modality importance ...
Nana Li, Jiayu Wang, Zuhe Li, Zhipeng Weng, Yihong Wang, Yushan Pan   +5 more
doaj   +1 more source

A review of the potential impacts of artificial lights on fish and wildlife and how this may apply to cannabis cultivation

California Fish and Wildlife Journal, 2020
Artificial lighting is used at cannabis cultivation sites in California to promote yield, for task lighting, and to provide security. While our understanding of how fish and wildlife respond to the artificial lights associated with cannabis cultivation
Lindsey N. Rich, Erin Ferguson, Ange Darnell Baker, Erin Chappell   +3 more
doaj   +1 more source

Prediction Model of Wastewater Pollutant Indicators Based on Combined Normalized Codec

Mathematics, 2022
Effective prediction of wastewater treatment is beneficial for precise control of wastewater treatment processes. The nonlinearity of pollutant indicators such as chemical oxygen demand (COD) and total phosphorus (TP) makes the model difficult to fit and
Chun-Ming Xu, Jia-Shuai Zhang, Ling-Qiang Kong, Xue-Bo Jin, Jian-Lei Kong, Yu-Ting Bai, Ting-Li Su, Hui-Jun Ma, Prasun Chakrabarti   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Multi-Scale Feature Mixing of Language Model Embeddings for Enhanced Prediction of Submitochondrial Protein Localization

Algorithms
Accurate prediction of submitochondrial localization is fundamental to understanding mitochondrial biogenesis and cellular metabolic pathways. While deep representations from pre-trained protein language models (pLMs) have significantly advanced the ...
Rong Wang, Menghua Wang, Yibo Wu, Lixiang Yang, Xiao Wang   +4 more
doaj   +1 more source

THE LINK BETWEEN CIRCADIAN CLOCK AND TUMORIGENESIS

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2021
The circadian clock is fundamental for allowing the human body to work properly. Studies demonstrated that circadian disruption is a risk factor for a lot of pathological states and in this Review, the idea is to focus on tumorigenesis.
Arianna DANERI, ADRIAN LUPUȘOR, Ion MOLDOVANU, Victor VOVC   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source