Results 61 to 70 of about 3,771,203 (333)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Modeling a Microtubule Filaments Mesh Structure from Confocal Microscopy Imaging

Micromachines, 2020
This study introduces a modeling method for a supermolecular structure of microtubules for the development of a force generation material using motor proteins.
Yutaka Ueno, Kento Matsuda, Kaoru Katoh, Akinori Kuzuya, Akira Kakugo, Akihiko Konagaya   +5 more
doaj   +1 more source

High-Order Model-Free Adaptive Iterative Learning Control of Pneumatic Artificial Muscle With Enhanced Convergence

IEEE transactions on industrial electronics (1982. Print), 2020
Pneumatic artificial muscles (PAMs) have been widely used in actuation of medical devices due to their intrinsic compliance and high power-to-weight ratio features. However, the nonlinearity and time-varying nature of PAMs make it challenging to maintain
Qingsong Ai, Da Ke, Jie Zuo, W. Meng, QUAN LIU, Zhiqiang Zhang, S. Xie   +6 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Shape-Memory Polymeric Artificial Muscles: Mechanisms, Applications and Challenges

Molecules, 2020
Shape-memory materials are smart materials that can remember an original shape and return to their unique state from a deformed secondary shape in the presence of an appropriate stimulus.
Yujie Chen, Chi Chen, Hafeez Ur Rehman, Xu Zheng, Hua Li, Hezhou Liu, Mikael S. Hedenqvist   +6 more
doaj   +1 more source

Sensory supplementation system based on electrotactile tongue biofeedback of head position for balance control [PDF]

, 2008
The present study aimed at investigating the effects of an artificial head position-based tongue-placed electrotactile biofeedback on postural control during quiet standing under different somatosensory conditions from the support surface.
Asai, Bach-y-Rita, Bach-y-Rita, Bernard-Demanze, Cenciarini, Danilov, Day, Fitzpatrick, Green, Horak, Inglis, Isableu, Jacques Demongeot, Kavounoudias, Ledin, Maki, Massion, Meyer, Nicolas Pinsault, Nicolas Vuillerme, Olivier Chenu, Peterka, Peterka, Picard, Priplata, Sampaio, Trulsson, Tyler, Vaillant, van Boven, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Yohan Payan, Yuri Danilov   +43 more
core   +3 more sources

Stiffness Graded Electroactive Artificial Muscle

Advanced Functional Materials, 2022
AbstractIn nature, hydrostatic, endo‐ and exo‐skeletons are widely observed, and provide essential rigidity and anchoring points for the application of muscular forces. The efficient interface between a hard skeleton and soft muscle in biology is made possible by a complex hierarchy of structures and composite materials, extending from the nano‐ to the
Majid Taghavi, Hsing‐Yu Chen, Andrew T. Conn, Jonathan Rossiter   +3 more
openaire   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mixed phase activated artificial muscle

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
This article presents the mixed phase as the pressure medium of hydraulic artificial muscles, which has rarely been mentioned before. Then a novel mixed phase activated artificial muscle is designed.
Wanda ZHAO, He XU, Auysakul JUTAMANEE, Mingyu HU, Chang LI, Le ZHU   +5 more
doaj   +1 more source

Plant‐Like Tropisms in Artificial Muscles

Advanced Materials, 2023
Helical plants have the ability of tropisms to respond to natural stimuli, and biomimicry of such helical shapes into artificial muscles has been vastly popular. However, the shape‐mimicked actuators only respond to artificially provided stimulus, they are not adaptive to variable natural conditions, thus being unsuitable for real‐life applications ...
Shazed Aziz, Xi Zhang, Sina Naficy, Bidita Salahuddin, Edwin W. H. Jager, Zhonghua Zhu   +5 more
openaire   +3 more sources