Results 41 to 50 of about 3,204,522 (342)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Advancing sustainability in the food and nutrition system: a review of artificial intelligence applications

Frontiers in Nutrition, 2023
Promoting sustainability in food and nutrition systems is essential to address the various challenges and trade-offs within the current food system. This imperative is guided by key principles and actionable steps, including enhancing productivity and ...
Zahra Namkhah, Seyedeh Fatemeh Fatemi, A. Mansoori, Saeid Nosratabadi, M. Ghayour-Mobarhan, S. Sobhani   +5 more
semanticscholar   +1 more source

Enzymatic and microbial routes to bioplastics: The green chemistry frontier of biopolymers

FEBS Open Bio, EarlyView.
Microbial biosynthesis and engineered enzyme platforms are expanding the design space of polyhydroxyalkanoate bioplastics. By combining fermentation, PHA synthase engineering and cell‐free modular systems, tailored biodegradable polymers can be produced with tunable properties, supporting more sustainable materials and future circular bioeconomy ...
Giovanni Gallo, Emma Piccoli, Luca Bombardi, Martina Aulitto, Salvatore Fusco   +4 more
wiley   +1 more source

Withholding artificial nutrition and hydration [PDF]

Journal of Medical Ethics, 2013
This special issue, Withholding artificial nutrition and hydration , comprises several papers, commentaries and responses centred largely around the issues raised by the 2011 decision of the English Court of Protection in W v M .i In that case, the mother of an adult patient applied for the withdrawal of life-sustaining treatment (specifically ...
openaire   +2 more sources

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Artificial Nutrition and Hydration

, 2015
Decreased appetite or inability to tolerate or enjoy food and fluids is often a hallmark of the terminal phase of an illness. Discussions and decisions regarding initiating or withholding artificial nutrition and hydration at the end of life are guided by goals of care, evaluation of benefits and burden, ethical and cultural considerations, and the ...
Michelle S. Gabriel, Jennifer A. Tschanz
openaire   +2 more sources

Machine Learning-Based Approach towards Identification of Pharmaceutical Suspensions Exploiting Speckle Pattern Images

Sensors
Parenteral artificial nutrition (PAN) is a lifesaving medical treatment for many patients worldwide. Administration of the wrong PAN drug can lead to severe consequences on patients’ health, including death in the worst cases.
Valentina Bello, Luca Coghe, Alessia Gerbasi, Elena Figus, Arianna Dagliati, Sabina Merlo   +5 more
doaj   +1 more source

Parenteral Nutrition in Liver Resection

Journal of Nutrition and Metabolism, 2012
Albeit a very large number of experiments have assessed the impact of various substrates on liver regeneration after partial hepatectomy, a limited number of clinical studies have evaluated artificial nutrition in liver resection patients.
Carlo Chiarla, Ivo Giovannini, Felice Giuliante, Francesco Ardito, Maria Vellone, Agostino Maria De Rose, Gennaro Nuzzo   +6 more
doaj   +1 more source

Artificial Nutritional Support Registries: systematic review.

Nutricion hospitalaria, 2009
Introduction: The nutritional registries are data bases through which we obtain the information to understand the nutrition of populations. Several main nutrition societies of the world have these types of registries, outstanding the NADYA (Home artificial and Ambulatory nutrition) group in Spain.
Castelló Botía, Isabel, Wanden-Berghe, Carmina, Sanz Valero, Javier   +2 more
openaire   +5 more sources

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source