Results 121 to 130 of about 79,942 (242)

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Differential negative dominance by KCNA2 variants associated with global developmental delay suggests KCNA2 haploinsufficiency in humans

The Journal of Physiology, EarlyView.
Abstract figure legend Potassium‐selective KV1.2 channels are encoded by the KCNA2 gene and regulate electrical signalling in neurons. KCNA2 genetic variants are associated with epileptic and developmental encephalopathy. We characterized two variants that subtly alter the channel's amino acid composition, p.H310D and p.G318D.
Pei Xin Boon, Amaia Jauregi‐Miguel, S. Suheda Yasarbas, Serena Pozzi, Urban Karlsson, Ammar Husami, Charmaine Ko, Amelle Shillington, Antonios Pantazis   +8 more
wiley   +1 more source

Relationship between Potential Sperm Factors Involved in Oocyte Activation and Sperm DNA Fragmentation with Intra-Cytoplasmic Sperm Injection Clinical Outcomes

Cell Journal, 2016
Objective: The present study aimed to simultaneously evaluate the association between expression of three potential factors [post-acrosomal sheath WW domain-binding protein (PAWP), phospholipase Cζ (PLCζ), and truncated form of the kit receptor (TR ...
Marziyeh Tavalaee, Abbas Kiani-Esfahani, Mohammad Hossein Nasr-Esfahani   +2 more
doaj  

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, Volume 14, Issue 4, Page 978-991, May 2026.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Molecular bases of insect odorant receptor function: specificity and evolution

Biological Reviews, Volume 101, Issue 2, Page 1036-1049, April 2026.
ABSTRACT Insect odorant receptors (ORs) are a class of chemoreceptors that insects use to detect volatile cues in their environment. In recent years, major advances in the field of structural biology have made it possible to obtain the first structures of insect ORs.
Zibo Li, Abhinob Baruah, Sridevi Bhamidipati, Nicolas Montagné, Emmanuelle Jacquin‐Joly, Camille Meslin   +5 more
wiley   +1 more source

When Benign Masquerades as Malignant: A Case of Expansively Growing Ovarian Leiomyoma Challenging Preoperative and Intraoperative Diagnosis

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Ovarian leiomyoma (OL) is an exceedingly rare benign tumor that originates from ovarian smooth muscle cells and accounts for approximately 0.5%–1% of all benign ovarian neoplasms. To date, around 100 cases have been documented worldwide.
Xi Luo, Neng Jing Yin, Xiao Ying Fan, Ling Li Zhang, Li Sha Zou   +4 more
wiley   +1 more source

Comparative analysis of morphology, growth performance and gonadal development between the hybrid crab (Scylla serrata ♀ × S. paramamosian ♂) and S. serrata

Journal of the World Aquaculture Society, Volume 57, Issue 2, April 2026.
Abstract Interspecific hybridization, through integrating genetic resources across distinct species, serves as a pivotal strategy for improving yield, stress resistance, and quality in aquacultural species. To evaluate the performance of hybrid crab (Scylla serrata ♀ × S.
Huanyu Zhang, Bihui Chao, Wenxiao Cui, Shaopan Ye, Shihao Shi, Peixun Chen, Mhd Ikhwanuddin, Hongyu Ma   +7 more
wiley   +1 more source

Evaluation of PLCζ and PAWP Expression in Globozoospermic Individuals

Cell Journal, 2016
Objective: Globozoospermia is a rare type of teratozoospermia with incidence of 0.1% among infertile individuals. Phospholipase C zeta (PLCζ) and postacrosomal sheath WW domain binding protein (PAWP) are the main candidates in sperm taking ...
Majid Kamali-Dolat Abadi, Marziyeh Tavalaee, Abdolhossein Shahverdi, Mohammad Hossein Nasr-Esfahani   +3 more
doaj  

Seasonal changes in sexual maturity and fecundity, and HCG-induced breeding of the catfish, Heterobranchus longifilis val. (claridae), reared in Ebrie Lagoon (Ivory Coast) [PDF]

, 1986
Oocyte maturation and ovulation were induced with human chorionic gonadotropin (HCG) in the African catfish, #Heterobranchus longifilis$. Females with a mean oocyte diameter of at least 1.1 mm were used.
Legendre, Marc
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