Results 41 to 50 of about 3,269,302 (338)

Endoscopic treatment of Kaposi’s sarcoma in a heart transplant patient

Вестник трансплантологии и искусственных органов
Kaposi’s sarcoma (KS) is a malignant tumor caused by human herpesvirus 8. Due to etiological and pathogenetic factors, this type of tumor is common among patients with immunodeficiency of various genesis.
M. T. Bekov, I. V. Pashkov, N. P. Mozheiko, N. N. Koloskova, K. S. Smirnov, Ya. S. Yakunin, M. V. Olkhovskaya, O. M. Tsirulnikova, S. V. Gautier   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A Critical Review of the CRISPR-Cas Technology in the Detection of SARS-CoV-2 Variants

Canadian Journal of Infectious Diseases and Medical Microbiology
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still going on, and as the epidemic situation continues, the genome of SARS-CoV-2 is also mutating and evolving, resulting in more and more SARS-
Jie Zhang, Juezhuo Li, Jiawei Zhou, Jiaye Zhong, Yue Xu, Xiaolei Mao, Minghui Xu, Shuyin Luo, Yi Yang, Ruiyao Hu, Dong-Ang Liu, Shiyu Chen, Yuting Qiu, Keyi Chen, Jinghua Yuan, Xinling Zhang, Xiaoping Li   +16 more
doaj   +1 more source

Application of combined endoscopic treatment of patients with bronchial stenosis after lung transplantation using thulium laser, balloon dilation, cryoablation, and airway stenting

Вестник трансплантологии и искусственных органов
Bronchial stenosis (BS) is a persistent, breathing-independent narrowing of the bronchial lumen, primarily brought on by scar and/or granulation tissue.
M. T. Bekov, I. V. Pashkov, K. S. Smirnov, Ya. S. Yakunin, E. F. Shigaev, A. Z. Guluev, T. S. Kryukova, O. M. Tsirulnikova, S. V. Gautier   +8 more
doaj   +1 more source

Regenerative and hepatospecific activity of total RNA from xenogenic bone marrow cells

Вестник трансплантологии и искусственных органов, 2021
Objective: to study the peculiarities of the induction effect of total RNA (tRNA) from xenogenic bone marrow cells (BMCs) on regeneration processes in the recipient's native liver with extensive liver resection using an adoptive transfer model. Materials
N. A. Onishchenko, A. O. Nikolskaya, Z. Z. Gonikova, L. A. Kirsanova, M. Yu. Shagidulin, V. I. Sevastianov   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The role of apoptotic bone marrow cells in activation of liver regeneration

Вестник трансплантологии и искусственных органов, 2022
Objective: using an adoptive transfer model to study the cellular mechanisms involved in the formation of the initial stage of liver regeneration during intraperitoneal injection of a healthy recipient with apoptotic bone marrowderived mononuclear cells (
N. A. Onishchenko, A. O. Nikolskaya, Z. Z. Gonikova, L. A. Kirsanova, M. Yu. Shagidulin, V. I. Sevastianov   +5 more
doaj   +1 more source

Artificial Organs as a Bridge to Transplantation

Artificial Cells, Blood Substitutes, and Biotechnology, 2003
Current organ shortage is estimated to keep outpacing demand for years to come. Among the advocated strategies, artificial and bioartificial devices may prove beneficial to a wide category of patients on transplant waiting lists. Bionic organ science allows to reproduce organ architecture and function through a complex interplay of cellular and ...
Famulari A, De Simone P, Verzaro R, Iaria G, Polisetti F, Rascente M, Aureli A   +6 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Organ-on-a-chip meets artificial intelligence in drug evaluation

Theranostics, 2023
Drug evaluation has always been an important area of research in the pharmaceutical industry. However, animal welfare protection and other shortcomings of traditional drug development models pose obstacles and challenges to drug evaluation.
Shiwen Deng, Caifeng Li, Junxian Cao, Zhao Cui, Jiang Du, Z. Fu, Han Yang, Peng Chen   +7 more
semanticscholar   +1 more source