Results 71 to 80 of about 1,603,738 (220)

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu, Lisa Zimmer, Dimitra Vlachopoulou, Elias Haj‐Yehia, Julia Hoffmann, Lars Michel, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Matthias Totzeck, Tienush Rassaf   +10 more
wiley   +1 more source

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

Large Language Model‐Based Localization of Premature Ventricular Contraction Origins: A Retrospective Diagnostic Accuracy Study

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Accurate localization of premature ventricular contraction (PVC) origin from 12‐lead electrocardiography (ECG) is important for procedural planning in catheter ablation. Although convolutional neural network (CNN)‐based models have shown promising diagnostic performance, they require task‐specific training and remain limited in ...
Kazuhisa Matsumoto, Yuya Fujisaki, Syunta Higuchi, Masataka Narita, Wataru Sasaki, Tsukasa Naganuma, Naomichi Tanaka, Daisuke Kawano, Kei Matsumoto, Wataru Yoshino, Yoshifumi Ikeda, Ritsushi Kato, Hitoshi Mori   +12 more
wiley   +1 more source

Modelling the pacemaker in event-B: towards methodology for reuse

, 2012
The cardiac pacemaker is one of the system modelling problems posed to the Formal Methods community by the Grand Challenge for Dependable Systems Evolution.
Poppleton, Michael, Rezazadeh, Abdolbaghi   +1 more
core   +1 more source

The Vestibular Implant Input Interacts with Residual Natural Function

Frontiers in Neurology, 2017
ObjectivePatients with bilateral vestibulopathy (BV) can still have residual “natural” function. This might interact with “artificial” vestibular implant input (VI-input). When fluctuating, it could lead to vertigo attacks.
Raymond van de Berg, Raymond van de Berg, Nils Guinand, Maurizio Ranieri, Samuel Cavuscens, T. A. Khoa Nguyen, Jean-Philippe Guyot, Florence Lucieer, Dmitrii Starkov, Herman Kingma, Herman Kingma, Marc van Hoof, Marc van Hoof, Angelica Perez-Fornos   +13 more
doaj   +1 more source

Arctic lake trout (Salvelinus namaycush) show evidence of seasonal acclimation of cardiac adrenergic sensitivity but not heat tolerance

Journal of Fish Biology, EarlyView.
Abstract Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to ...
Emily P. Williams, Les N. Harris, Jean‐Sébastien Moore, Ella K. Middleton, Shira A. Berkelhammer, Ben Speers‐Roesch, Matthew J. H. Gilbert   +6 more
wiley   +1 more source

Pacemaker Arrhythmias and Electrocardiographic Recognition of Pacemakers

, 1973
Adequate interpretation of pacemaker arrhythmias requires a thorough knowledge of the clinical situation in which they appear, the type of pacemaker, and modality of stimulation used, as well as knowledge of the corresponding electronic specifications ...
Castellanos, AGUSTIN, Lemberg, LOUIS
core   +1 more source

Perceived Social Support in Atrial Fibrillation Care: Implications for Nurse‐Led Education and Follow‐Up

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To describe the level, content and sources of perceived social support among adults with atrial fibrillation, and to identify clinical, lifestyle and care pathway factors associated with perceived support. Design A cross‐sectional survey design.
Outi Kähkönen, Niina Raitanen, Juha Hartikainen, Anna‐Mari Hekkala, Signe Stelling Risom, Tone M. Norekvål, Ying Lau, Ville Hautamäki, Anneli Vauhkonen   +8 more
wiley   +1 more source

The futuristic manifolds of REM sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since one of its first descriptions 70 years ago, rapid eye movement sleep has continually inspired and excited new generations of sleep researchers. Despite significant advancements in understanding its neurocircuitry, underlying mechanisms and microstates, many questions regarding its function, especially beyond the early neurodevelopment ...
Liborio Parrino, Ivana Rosenzweig
wiley   +1 more source

Modeling experiments on pacemaker interactions in scyphomedusae [PDF]

, 2009
Scyphozoan jellyfish are free-swimming gelatinous organisms whose nervous system includes a motor nerve net that controls swimming. Swim contractions originate in a network of distributed pacemakers found in the marginal rhopalia, which are located ...
NC DOCKS at The University of North Carolina Wilmington, Hayward, Rodney T.   +1 more
core