Results 31 to 40 of about 468,950 (263)

Language model and its interpretability in biomedicine: A scoping review

iScience
Summary: With advancements in large language models, artificial intelligence (AI) is undergoing a paradigm shift where AI models can be repurposed with minimal effort across various downstream tasks.
Daoming Lyu, Xingbo Wang, Yong Chen, Fei Wang   +3 more
doaj   +1 more source

Size of population required for artificial selection

Genetical Research, 1980
SUMMARYIt is widely acknowledged that genetic drift is an important source of variation in response to artificial directional selection. How large should a selection line be in order to reduce the effect of genetic drift to an acceptably low level?This paper investigates two criteria that can be used to answer this question in relation to short-term ...
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Association among family and domestic violence, sleep disturbance, anxiety, suicidal and self-harm ideation: a chained mediation modeling analysis

Frontiers in Psychology
IntroductionFamily and domestic violence (FDV) is closely related to suicidal and self-harm ideation (SSI), but the research in this regard is insufficient in China.MethodsBased on the data from the 2022 Psychology and Behavior Investigation of Chinese ...
Chenyu Yan, Chenyu Yan, Yueping Song, Yueping Song, Yueping Song, Siyuan Liu, Siyuan Liu, Siyuan Liu, Wannian Liang   +8 more
doaj   +1 more source

Radial analysis and scaling of urban land use

Scientific Reports, 2021
We determine the functional form and scaling law of radial artificial land use profiles in 300 European functional urban areas (FUAs). These profiles, starting from a fully artificial surface in the city center, decrease exponentially, the faster the ...
Rémi Lemoy, Geoffrey Caruso
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Safer not to know? Shaping liability law and policy to incentivize adoption of predictive AI technologies in the food system

Frontiers in Artificial Intelligence, 2023
Governments, researchers, and developers emphasize creating “trustworthy AI,” defined as AI that prevents bias, ensures data privacy, and generates reliable results that perform as expected.
Carrie S. Alexander, Aaron Smith, Renata Ivanek   +2 more
doaj   +1 more source

On the theory of artificial selection in finite populations

Genetical Research, 1969
The effect of selection on individual performance for a quantitative trait is studied theoretically for populations of finite size. The trait is assumed to be affected by environmental error and by segregation at a single locus. Exact formulae are derived to predict the change in gene frequency at this locus, initially by finding the probability ...
openaire   +2 more sources

Artificial selection with differing population structures

Genetical Research, 1980
SUMMARYThe effect of subdivision of a population on response to artificial directional selection for abdominal bristle number inDrosophila melanogasterwas compared using large, replicated lines. Three different population structures were compared: (i) selection in an Undivided, large population with 50 pairs of parents (treatment U); (ii) selection in ...
K. A. Rathie, F. W. Nicholas
openaire   +1 more source