Results 1 to 10 of about 6,085,254 (274)

Genetic and environmental risk factors of asthma: a narrative review

Frontiers in Immunology
Asthma is a heterogeneous and polygenic disease, with numerous genes involved in immune regulation and respiratory epithelial function. However, currently identified genetic variants explain only part of asthma heritability.
N.K. Altynova, L.P. Lebedeva, M.S. Abdullayeva, A.M. Kassymbekova, A.M. Kassymbekova, K. Yergali, N. Homaira, L.B. Djansugurova   +7 more
doaj   +1 more source

Little evidence of inbreeding depression for birth mass, survival and growth in Antarctic fur seal pups

Scientific Reports
Inbreeding depression, the loss of offspring fitness due to consanguineous mating, is generally detrimental for individual performance and population viability.
A. J. Paijmans, A. L. Berthelsen, R. Nagel, F. Christaller, N. Kröcker, J. Forcada, J. I. Hoffman   +6 more
doaj   +1 more source

Exploring the effects of ecological parameters on the spatial structure of genetic tree sequences

Peer Community Journal
Geographic space is a fundamental dimension of evolutionary change, determining how individuals disperse and interact with each other. Consequently, space has an important influence on the structure of genealogies and the distribution of genetic variants
Ianni-Ravn, Mariadaria K., Petr, Martin, Racimo, Fernando   +2 more
doaj   +1 more source

Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface

BMC Genetics, 2020
Background Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce.
Francois Besnier, Monica F. Solberg, Alison C. Harvey, Gary R. Carvalho, Dorte Bekkevold, Martin I. Taylor, Simon Creer, Einar E. Nielsen, Øystein Skaala, Fernando Ayllon, Geir Dahle, Kevin A. Glover   +11 more
doaj   +1 more source

Genetics and context for precision health in Greater Boston

Nature Communications
Mass General Brigham, an integrated healthcare system based in the Greater Boston area of Massachusetts, annually serves 1.5 million patients. We established the Mass General Brigham Biobank (MGBB), currently encompassing 142,238 participants, to unravel
Satoshi Koyama, Ying Wang, Kaavya Paruchuri, Md Mesbah Uddin, So Mi J. Cho, Sarah M. Urbut, Yang Sui, Akl C. Fahed, Himani Kamineni, Sara Haidermota, Whitney E. Hornsby, Robert C. Green, Mark J. Daly, Benjamin M. Neale, Patrick T. Ellinor, Jordan W. Smoller, Susan A. Slaugenhaupt, Matthew S. Lebo, Elizabeth W. Karlson, Alicia R. Martin, Pradeep Natarajan   +20 more
doaj   +1 more source

gPGA: GPU Accelerated Population Genetics Analyses. [PDF]

PLoS ONE, 2015
The isolation with migration (IM) model is important for studies in population genetics and phylogeography. IM program applies the IM model to genetic data drawn from a pair of closely related populations or species based on Markov chain Monte Carlo ...
Chunbao Zhou, Xianyu Lang, Yangang Wang, Chaodong Zhu   +3 more
doaj   +1 more source

The evolutionary history of LysM-RLKs (LYKs/LYRs) in wild tomatoes

BMC Evolutionary Biology, 2019
Background The LysM receptor-like kinases (LysM-RLKs) are important to both plant defense and symbiosis. Previous studies described three clades of LysM-RLKs: LysM-I/LYKs (10+ exons per gene and containing conserved kinase residues), LysM-II/LYRs (1–5 ...
Sarah Richards, Laura E. Rose
doaj   +1 more source

The population genetics of evolutionary rescue. [PDF]

PLoS Genetics, 2014
Evolutionary rescue occurs when a population that is threatened with extinction by an environmental change adapts to the change sufficiently rapidly to survive. Here we extend the mathematical theory of evolutionary rescue.
H Allen Orr, Robert L Unckless
doaj   +1 more source

Demographic history and genomics of local adaptation in blue tit populations

Evolutionary Applications, 2020
Understanding the genomic processes underlying local adaptation is a central aim of modern evolutionary biology. This task requires identifying footprints of local selection but also estimating spatio‐temporal variations in population demography and ...
Charles Perrier, Quentin Rougemont, Anne Charmantier   +2 more
doaj   +1 more source

Population genetics and GWAS: A primer. [PDF]

PLoS Biology, 2018
This primer provides some background to help non-specialists understand a new theoretical evolutionary genetics study that helps explain why thousands of variants of small effect contribute to complex traits.
Greg Gibson
doaj   +1 more source