Results 21 to 30 of about 1,352,174 (294)

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Nature Communications, 2020
Multi-nucleotide variants (MNV) are genetic variants in close proximity of each other on the same haplotype whose functional impact is difficult to predict if they reside in the same codon. Here, Wang et al. use the gnomAD dataset to assemble a catalogue
Qingbo Wang, Emma Pierce-Hoffman, Beryl B. Cummings, Jessica Alföldi, Laurent C. Francioli, Laura D. Gauthier, Andrew J. Hill, Anne H. O’Donnell-Luria, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Konrad J. Karczewski, Daniel G. MacArthur   +11 more
doaj   +1 more source

Genetic draft, selective interference, and population genetics of rapid adaptation [PDF]

, 2013
To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare.
Neher, Richard A.
core   +1 more source

Mantel test in population genetics

Genetics and Molecular Biology, 2013
The comparison of genetic divergence or genetic distances, estimated by pairwise F ST and related statistics, with geographical distances by Mantel test is one of the most popular approaches to evaluate spatial processes driving population structure ...
José Alexandre F. Diniz-Filho, Thannya N. Soares, Jacqueline S. Lima, Ricardo Dobrovolski, Victor Lemes Landeiro, Mariana Pires de Campos Telles, Thiago F. Rangel, Luis Mauricio Bini   +7 more
doaj   +1 more source

Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots

Nature Communications, 2022
The inherited basis of body fat distribution is not fully understood. Here, the authors use genetic data and MRI-derived measures of local adiposity to highlight fat depot-specific genetic architecture with implications for cardiometabolic health.
Saaket Agrawal, Minxian Wang, Marcus D. R. Klarqvist, Kirk Smith, Joseph Shin, Hesam Dashti, Nathaniel Diamant, Seung Hoan Choi, Sean J. Jurgens, Patrick T. Ellinor, Anthony Philippakis, Melina Claussnitzer, Kenney Ng, Miriam S. Udler, Puneet Batra, Amit V. Khera   +15 more
doaj   +1 more source

Transposon-induced epigenetic silencing in the X chromosome as a novel form of dmrt1 expression regulation during sex determination in the fighting fish

BMC Biology, 2022
Background Fishes are the one of the most diverse groups of animals with respect to their modes of sex determination, providing unique models for uncovering the evolutionary and molecular mechanisms underlying sex determination and reversal.
Le Wang, Fei Sun, Zi Yi Wan, Zituo Yang, Yi Xuan Tay, May Lee, Baoqing Ye, Yanfei Wen, Zining Meng, Bin Fan, Yuzer Alfiko, Yubang Shen, Francesc Piferrer, Axel Meyer, Manfred Schartl, Gen Hua Yue   +15 more
doaj   +1 more source

Neutral genomic signatures of host-parasite coevolution

BMC Evolutionary Biology, 2019
Background Coevolution is a selective process of reciprocal adaptation in hosts and parasites or in mutualistic symbionts. Classic population genetics theory predicts the signatures of selection at the interacting loci of both species, but not the ...
Daniel živković, Sona John, Mélissa Verin, Wolfgang Stephan, Aurélien Tellier   +4 more
doaj   +1 more source

Population genetics of forest trees.

Silva Fennica, 1982
The publication comprises proceedings of a conference held in Helsinki in 1981. Forest tree populations are investigated for population genetic structure, mating systems, mechanisms of genetic adaptation and ecological adaptation.
Tigerstedt, P.
doaj   +1 more source

Population genetics in compressible flows

, 2011
We study competition between two biological species advected by a compressible velocity field. Individuals are treated as discrete Lagrangian particles that reproduce or die in a density-dependent fashion.
A. Kolmogorov, B. A. Whitton, C. Gardiner, David R. Nelson, J. F. Crow, M. Kimura, Mogens H. Jensen, N. G. van Kampen, Roberto Benzi, Simone Pigolotti, T. Bohr   +10 more
core   +1 more source

Population genetics models of local ancestry

, 2012
Migrations have played an important role in shaping the genetic diversity of human populations. Understanding genomic data thus requires careful modeling of historical gene flow.
Falush, Li, Simon Gravel
core   +1 more source

Dualities in population genetics: a fresh look with new dualities [PDF]

, 2014
We apply our general method of duality, introduced in [Giardina', Kurchan, Redig, J. Math. Phys. 48, 033301 (2007)], to models of population dynamics.
Carinci, Gioia, Giardina', Cristian, Giberti, Claudio, Redig, Frank   +3 more
core   +2 more sources