Results 31 to 40 of about 1,352,174 (294)

Imputation Estimators Partially Correct for Model Misspecification [PDF]

, 2010
Inference problems with incomplete observations often aim at estimating population properties of unobserved quantities. One simple way to accomplish this estimation is to impute the unobserved quantities of interest at the individual level and then take ...
Minin, Vladimir N., O'Brien, John D., Seregin, Arseni   +2 more
core   +1 more source

Using neutral cline decay to estimate contemporary dispersal: a generic tool and its application to a major crop pathogen [PDF]

, 2013
Dispersal is a key parameter of adaptation, invasion and persistence. Yet standard population genetics inference methods hardly distinguish it from drift and many species cannot be studied by direct mark-recapture methods.
Amil, Barton, Barton, Barton, Barton, Barton, Broquet, Brown, Burt, Carlier, Chen, Daguin, Dieckmann, Endler, Fisher, Gay, Giraud, Goudet, Guillot, Guillot, Halkett, Jones, Lapeyre de Bellaire, Lebreton, Lenormand, Lenormand, Lenormand, Lenormand, Lockwood, McCartney, McDonald, Mourichon, Neu, Pennisi, Rieux, Rieux, Robert, Ronce, Rousset, Rousset, Rousset, Saccheri, Sackett, Slatkin, Storey, Turelli, Zapater   +46 more
core   +1 more source

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

The evolution of moment generating functions for the Wright Fisher model of population genetics

, 2014
We derive and apply a partial differential equation for the moment generating function of the Wright-Fisher model of population ...
Hofrichter, Julian, Jost, Juergen, Tran, Tat Dat   +2 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Exploring the effects of ecological parameters on the spatial structure of genetic tree sequences

Peer Community Journal
Geographic space is a fundamental dimension of evolutionary change, determining how individuals disperse and interact with each other. Consequently, space has an important influence on the structure of genealogies and the distribution of genetic variants
Ianni-Ravn, Mariadaria K., Petr, Martin, Racimo, Fernando   +2 more
doaj   +1 more source

Epistatic regulation of growth in Atlantic salmon revealed: a QTL study performed on the domesticated-wild interface

BMC Genetics, 2020
Background Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce.
Francois Besnier, Monica F. Solberg, Alison C. Harvey, Gary R. Carvalho, Dorte Bekkevold, Martin I. Taylor, Simon Creer, Einar E. Nielsen, Øystein Skaala, Fernando Ayllon, Geir Dahle, Kevin A. Glover   +11 more
doaj   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Little evidence of inbreeding depression for birth mass, survival and growth in Antarctic fur seal pups

Scientific Reports
Inbreeding depression, the loss of offspring fitness due to consanguineous mating, is generally detrimental for individual performance and population viability.
A. J. Paijmans, A. L. Berthelsen, R. Nagel, F. Christaller, N. Kröcker, J. Forcada, J. I. Hoffman   +6 more
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source