Results 51 to 60 of about 1,464,312 (342)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Association among family and domestic violence, sleep disturbance, anxiety, suicidal and self-harm ideation: a chained mediation modeling analysis

Frontiers in Psychology
IntroductionFamily and domestic violence (FDV) is closely related to suicidal and self-harm ideation (SSI), but the research in this regard is insufficient in China.MethodsBased on the data from the 2022 Psychology and Behavior Investigation of Chinese ...
Chenyu Yan, Chenyu Yan, Yueping Song, Yueping Song, Yueping Song, Siyuan Liu, Siyuan Liu, Siyuan Liu, Wannian Liang   +8 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

An Artificial Plant Community Algorithm for the Accurate Range-Free Positioning of Wireless Sensor Networks

Sensors, 2023
The problem of positioning wireless sensor networks is an important and challenging topic in all walks of life. Inspired by the evolution behavior of natural plant communities and traditional positioning algorithms, a novel positioning algorithm based on
Zhengying Cai, Shan Jiang, Jiahuizi Dong, Sijia Tang   +3 more
doaj   +1 more source

Size of population required for artificial selection

Genetical Research, 1980
SUMMARYIt is widely acknowledged that genetic drift is an important source of variation in response to artificial directional selection. How large should a selection line be in order to reduce the effect of genetic drift to an acceptably low level?This paper investigates two criteria that can be used to answer this question in relation to short-term ...
openaire   +2 more sources

Dietary intake of artificial sweeteners by the Belgian population [PDF]

Food Additives & Contaminants: Part A, 2012
This study investigated whether the Belgian population older than 15 years is at risk of exceeding ADI levels for acesulfame-K, saccharin, cyclamate, aspartame and sucralose through an assessment of usual dietary intake of artificial sweeteners and specific consumption of table-top sweeteners.
Kevin, Huvaere, Stefanie, Vandevijvere, Moez, Hasni, Christine, Vinkx, Joris, Van Loco   +4 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Artificial intelligence, recessionary pressures and population health

Bulletin of the World Health Organization
Economic and labour policies have a considerable influence on health and well-being through direct financial impacts, and by shaping social and physical environments. Strong economies are important for public health investment and employment, yet the rapid rise of generative artificial intelligence (AI) has the potential to reshape economies ...
Occhipinti, Jo-An, Prodan, Ante, Hynes, William, Buchanan, John, Green, Roy, Burrow, Sharan, Eyre, Harris A, Skinner, Adam, Hickie, Ian B, Heffernan, Mark, Song, Yun Ju Christine, Ujdur, Goran, Tanner, Marcel   +12 more
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Predicting population fluctuations with artificial neural networks

Wildlife Biology, 1998
Successful predictions of population fluctuations are valuable in game management, as population estimates are instrumental in increasing the time available for management decisions. However, finding a population model which produces predictions accurate enough to be used for management purposes is often precluded due to scarcity ...
Jan Lindström, Hanna Kokko, Esa Ranta, Harto Lindén   +3 more
openaire   +1 more source