Results 91 to 100 of about 2,454,862 (267)

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Chiral nature of magnetic monopoles in artificial spin ice

New Journal of Physics, 2013
Micromagnetic properties of monopoles in artificial kagome spin ice systems are investigated using numerical simulations. We show that micromagnetics brings additional complexity into the physics of these monopoles that is, by essence, absent in spin ...
N Rougemaille, F Montaigne, B Canals, M Hehn, H Riahi, D Lacour, J-C Toussaint   +6 more
doaj   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Magnetotransport in Artificial Kagome Spin Ice [PDF]

Physical Review Applied, 2017
One of the most intriguing features of spin-ice materials is that their elementary excitations behave as emergent magnetic monopoles. While the properties of spin ices suggest applications in magnetism and spintronics, $a\phantom{\rule{0}{0ex}}r\phantom{\rule{0}{0ex}}t\phantom{\rule{0}{0ex}}i\phantom{\rule{0}{0ex}}f\phantom{\rule{0}{0ex}}i\phantom ...
openaire   +1 more source

Dynamic dependence to domain wall propagation through artificial spin ice [PDF]

, 2017
Domain wall propagation dynamics has been studied in nanostructured artificial kagome spin-ice structures. A stripline circuit has been used to provide localized pulsed magnetic fields within the artificial spin-ice (ASI) structure. This provides control
Chadha, M, W. R. Branford, Burn, DM, D. M. Burn, Branford, WR, M. Chadha   +5 more
core   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

Artificial Kagome Arrays of Nanomagnets: A Frozen Dipolar Spin Ice

, 2011
4 pages, 4 figures, 1 tableInternational audienceMagnetic frustration effects in artificial kagome arrays of nanomagnets are investigated using x-ray photoemission electron microscopy and Monte Carlo simulations.
O. Fruchart, M. Hehn, Bendounan, A., Canals, Benjamin, A. Duluard, A. Bendounan, Duluard, A., F. Maccherozzi, N. Rougemaille, B. Canals, F. Montaigne, D. Lacour, Montaigne, F., R. Belkhou, Lacour, D., S. El Moussaoui, Hehn, M., Moussaoui, S. El, Rougemaille, N., Belkhou, R., Fruchart, Olivier, Maccherozzi, F.   +21 more
core   +1 more source

Muon spin spectroscopy: magnetism, soft matter and the bridge between the two [PDF]

, 2014
LS would like to acknowledge financial support from the Swiss National Science Foundation, grant numbers PBFRP2-138632 and PBFRP2-142820. AD would like to acknowledge financial support from the UK Engineering and Physical Sciences Research Council, grant
Schulz, L, Nuccio L, Schulz L, Drew, AJ, Nuccio, L, Drew AJ   +5 more
core   +1 more source