Results 101 to 110 of about 2,454,862 (267)

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Dynamic Control of Topological Defects in Artificial Colloidal Ice

Scientific Reports, 2017
We demonstrate the use of an external field to stabilize and control defect lines connecting topological monopoles in spin ice. For definiteness we perform Brownian dynamics simulations with realistic units mimicking experimentally realized artificial ...
A. Libál, C. Nisoli, C. Reichhardt, C. J. Olson Reichhardt   +3 more
doaj   +1 more source

Computation‐Guided Tunnel Engineering Enhances O2 Transport and H2O2 Resistance of Fe(II)/α‐Ketoglutarate‐Dependent Dioxygenases

Advanced Science, EarlyView.
This study presents a computational tunnel engineering strategy in Fe(II)/α‐ketoglutarate‐dependent dioxygenases (αKGDs) to enhance oxygen (O2) transport, an essential molecule for αKGDs, and limit hydrogen peroxide (H2O2) entry, an inhibitor from the αKG supply system.
Huan Liu, Lunjie Wu, Liying Mao, Songyin Zhao, Hu Liu, Shiyi Xin, Donglin Zhao, Jie Gu, Yan Xu, Xinye Wang, Yao Nie   +10 more
wiley   +1 more source

Geometry driven intermediate states in artificial square ice structures

Communications Materials
Conventional approaches to studying nanomagnets often focus on the energetic relaxation from an initialized state to a final low-energy state, typically assuming a single spin-flip regime.
Hanu Arava, Ignacio Tapia, Timothy Cote, Justin S. Woods, Frank Barrows, John Fullerton, Paula Mellado   +6 more
doaj   +1 more source

Quantum Excitations in Quantum Spin Ice

Physical Review X, 2011
Recent work has highlighted remarkable effects of classical thermal fluctuations in the dipolar spin ice compounds, such as “artificial magnetostatics,” manifesting as Coulombic power-law spin correlations and particles behaving as diffusive “magnetic ...
Kate A. Ross, Lucile Savary, Bruce D. Gaulin, Leon Balents   +3 more
doaj   +1 more source

Experimental and theoretical evidences for the ice regime in planar artificial spin ices

Journal of Physics: Condensed Matter, 2018
Abstract In this work, we explore a kind of geometrical effect in the thermodynamics of artificial spin ices (ASI). In general, such artificial materials are athermal. Here, We demonstrate that geometrically driven dynamics in ASI can open up the panorama of exploring distinct ground states and thermally magnetic ...
R P Loreto, F S Nascimento, R S Gonçalves, J Borme, J C Cezar, C Nisoli, A R Pereira, C I L de Araujo   +7 more
openaire   +4 more sources

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Field angle dependent resonant dynamics of artificial spin ice lattices

, 2023
Artificial spin ice structures which are networks of coupled nanomagnets arranged on different lattices that exhibit a number of interesting phenomena are promising for future information processing.
Haldar, Arabinda
core   +1 more source

An Immediate‐Response Detection System for γ‐Hydroxybutyrate to Enhance Personal Safety in Social Environments

Advanced Science, EarlyView.
A graphene‐based electrical biosensor enables rapid and highly sensitive detection of GHB at 100 fm in both standard solutions and artificial urine, providing reliable point‐of‐need screening for drug‐facilitated sexual assault. The platform demonstrates strong selectivity, fast response, and a wide dynamic range, supporting accurate detection in ...
Jai Eun An, Jisung Kwak, Kyung Ho Kim, Chaeeun Kim, Sung Eun Seo, Nathaniel S. Hwang, Yong‐Sang Ryu, Hyun Seok Song, Oh Seok Kwon   +8 more
wiley   +1 more source

Focus on artificial frustrated systems

New Journal of Physics, 2014
Frustration in physics is the inability of a system to simultaneously satisfy all the competing pairwise interactions within it. The past decade has seen an explosion of activity involving engineering frustration in artificial systems built using ...
J Cumings, L J Heyderman, C H Marrows, R L Stamps   +3 more
doaj   +1 more source