Advanced Science, EarlyView.Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding +7 more
wiley +1 more source
Safety and Efficacy of Diquafosol Compared to Artificial Tears for the Treatment of Dry Eye: A Systematic Review and Meta-Analysis. [PDF]
Int J Mol SciSerrano-Robles JG +6 more
europepmc +1 more source
The efficacy of ocular surface assessment approaches in evaluating dry eye treatment with artificial tears. [PDF]
Sci Rep, 2022 Szczesna-Iskander DH +2 more
europepmc +1 more source
ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief
Advanced Science, EarlyView.ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng +19 more
wiley +1 more source
The application of hyaluronic acid-containing artificial tears on the ocular surface of children receiving orthokeratology contact lens treatment. [PDF]
Int J Med SciLee CY, Yang SF, Huang JY, Chang CK.
europepmc +1 more source
Randomized Controlled Study of Cooled vs Room-Temperature Artificial Tears for Reducing Ocular Surface Irritation After Intravitreal Injection. [PDF]
J Vitreoretin Dis, 2023 Mani S +4 more
europepmc +1 more source
Advanced Science, EarlyView.A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang +15 more
wiley +1 more source
Microbial Contamination of Preservative-Free Artificial Tears Based on Instillation Techniques. [PDF]
Pathogens, 2022 Lee JH, Kang MJ, Sim HE, Hwang JH.
europepmc +1 more source
Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration
Advanced Science, EarlyView.This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya +10 more
wiley +1 more source
Cationic nanoemulsion vs. 0.15% sodium hyaluronate artificial tears in the healing process following modern surface keratorefractive surgery. [PDF]
Eur J Ophthalmol, 2023 Jaworski D +6 more
europepmc +1 more source