Results 191 to 200 of about 330,962 (287)

Ligand-enabled next-generation glycosyl Stille cross-coupling for the stereospecific synthesis of sterically hindered aryl C-glycosides. [PDF]

Nat Commun
Yang B, Chen S, Han Y, Zhu B, Sang J, Zhu W, Li Y, Zhu F.   +7 more
europepmc   +1 more source

Mechanism-Inspired Ligand Design for Efficient Copper-Catalyzed C-N Coupling of Aryl and Heteroaryl Chlorides. [PDF]

J Am Chem Soc
Zhao W, Amberg WM, Rao G, Xie Y, Pierson CN, Fantasia SM, Rummelt SM, Püntener K, Britt RD, Hartwig JF.   +9 more
europepmc   +1 more source

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution

Angewandte Chemie International Edition, EarlyView.
Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

Homogeneous Reductant Facilitated Cross-Electrophile Coupling of Aryl Bromides with NHP Esters. [PDF]

Org Lett
Kundu A, Kim S, Hazari N, Uehling MR, Yalla R.   +4 more
europepmc   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Nickel-Catalyzed Aryl Group Interconversion: A Non-Equilibrium Strategy for Aryl Nitrile Synthesis. [PDF]

JACS Au
Tanaka H, Moriya E, Onozawa Y, Yamaguchi J.   +3 more
europepmc   +1 more source

Radical Cascade Combining Cross‐Olefin Coupling with the Smiles‐Truce Rearrangement

Angewandte Chemie International Edition, EarlyView.
We present a cobalt‐catalysed radical cascade that efficiently merges two alkene starting materials to form multiple bonds in a single step. The process begins with a cobalt‐catalysed hydrogen‐atom transfer‐to a styrene double bond, followed by a Giese addition.
Jingyang Qin, Lucas Popek, Moritz Wyrtki, Christopher J. Teskey   +3 more
wiley   +1 more source

Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors. [PDF]

Angew Chem Int Ed Engl
Xu Z, Mukherjee P, Gossert S, Thomas S, Vasilev VH, Welin ER, Tan Y, McKenna SM, Emmanuel MA, Hyster TK.   +9 more
europepmc   +1 more source

Photoredox-enabled late-stage functionalization of pyrrolidines in batch and flow: rapid access to benzothiazole hybrids as a new class of cholinesterase inhibitors. [PDF]

RSC Adv
Filipović A, Vučkovski M, Mićović D, Bondžić AM, Bondžić BP.   +4 more
europepmc   +1 more source

Platinum-Electrocatalyzed Divergent Nitrile Cross-Coupling. [PDF]

JACS Au
Xu W, Hu P, Zhong Y, Nie M, Lu Q.
europepmc   +1 more source