Results 131 to 140 of about 17,003 (187)
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Aryl Hydrocarbon Hydroxylase Inducibility in Laryngeal Carcinoma
Archives of Otolaryngology - Head and Neck Surgery, 1978The chief carcinogens of tobacco smoke--the polycyclic aromatic hydrocarbons--must be activated in the cells to exert their carcinogenic effect. This activation is carried out by the enzyme system aryl hydrocarbon hydroxylase (AHH). Mitogen-stimulated, human lymphocyte studies of AHH activity indicate wide individual variation, which is under strict ...
James H. Brandenburg +1 more
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ACTIVITY OF ARYL HYDROCARBON HYDROXYLASE IN PSORIATIC SKIN
The Lancet, 1979The activity of aryl hydrocarbon hydroxylase (A.H.H.), a microsomal mono-oxygenase, was reduced in epidermis from both the psoriatic lesions and clinically normal lesion-free skin from psoriatic patients. Induction of epidermal A.H.H. activity by benzanthracene was also significantly less than normal in both psoriatic lesions and in clinically normal ...
M.D. Rawlins, Sam Shuster, P. H. Chapman
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ARYL-HYDROCARBON-HYDROXYLASE INDUCIBILITY IN PATIENTS WITH CANCER
The Lancet, 1978Aryl-hydrocarbon-hydroxylase (A.H.H.) inducibility has been studied in the peripheral-blood lymphocytes of patients with squamous-cell lung cancer, of patients with cancer at other sites, and of controls matched for age, sex, social class, and smoking habits. The proportion of high inducers was significantly greater among patients with lung cancer (but
W. Duncan +4 more
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Acta Pharmacologica et Toxicologica, 2009
It is known from experiments on rats and mice that control and polycyclic aromatic hydrocarbon-induced activities of aryl hydrocarbon hydroxylase differ profoundly with regard to their inhibition by several compounds. In order to obtain information about
O. Pelkonen
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It is known from experiments on rats and mice that control and polycyclic aromatic hydrocarbon-induced activities of aryl hydrocarbon hydroxylase differ profoundly with regard to their inhibition by several compounds. In order to obtain information about
O. Pelkonen
semanticscholar +1 more source
Acta Pharmacologica et Toxicologica, 2009
The effects of 3-methylcholanthrene (MC) pretreatment on metabolism and mutagenic activation of dimethylnitrosamine (DMN) were studied with liver subfractions from two strains of mice differing genetically with respect to aromatic hydrocarbon ...
T. Aune +3 more
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The effects of 3-methylcholanthrene (MC) pretreatment on metabolism and mutagenic activation of dimethylnitrosamine (DMN) were studied with liver subfractions from two strains of mice differing genetically with respect to aromatic hydrocarbon ...
T. Aune +3 more
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Aryl hydrocarbon hydroxylase and 16?-hydroxylase in cultured human lymphocytes
Biochemical Genetics, 1976Aryl hydrocarbon hydroxylase and 16alpha-hydroxylase were examined in intact, cultured human lymphocytes. The two microsomal mixed-function oxygenases had different pH optima and showed competitive inhibition for enzyme induction and activity. Population distributions were lognormal for both enzymes, giving apparent evidence for polygenic control ...
D. L. Busbee +5 more
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Aryl Hydrocarbon Hydroxylase: Induction
1977Knowledge about the enzyme system responsible for the metabolism of aryl hydrocarbons dates back to the early studies of Conney et al. (1), who showed the enzyme(s) responsible for the oxidation of benzpyrene to be located in the microsomal fraction of the liver. In that study it was shown that the enzyme system required both NADPH and molecular oxygen
Kathy M. Robie +2 more
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Hydrocarbon-based oils as inducers of cutaneous aryl hydrocarbon hydroxylase
Toxicology Letters, 1982Petroleum-based oils applied to the skin of rats induced cutaneous aryl hydrocarbon hydroxylase activity. A heavy oil like Kuwait Crude induced benzo(a)pyrene (BaP) hydroxylase and diphenyloxazole (PPO) hydroxylase activities to levels obtained with Aroclor 1254, while a light oil like Fuel Oil No. 2 was less effective.
Isabel Martins +4 more
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Acta Pharmacologica et Toxicologica, 2009
The response of rat lung and liver ornithine decarboxylase (ODC) and aryl hydrocarbon hydroxylase (AHH) activities and lung benzo(a)pyrene (BP) metabolism was studied after exposing the rats to cigarette smoke. A close analysis of the time curves for ODC
H. Raunio +3 more
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The response of rat lung and liver ornithine decarboxylase (ODC) and aryl hydrocarbon hydroxylase (AHH) activities and lung benzo(a)pyrene (BP) metabolism was studied after exposing the rats to cigarette smoke. A close analysis of the time curves for ODC
H. Raunio +3 more
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Aryl Hydrocarbon Hydroxylase Activity in Rat Submandibular Glands [PDF]
Journal of Dental Research, 1986 The activities of aryl hydrocarbon hydroxylase and 7-ethoxycoumarin O-de-ethylase in the rat submandibular gland, both of which are normally very low, were increased about 10- and 25-fold, respectively, by administration of 3-methylcholanthrene. The increased activity of aryl hydrocarbon hydroxylase was inhibited by 7,8-benzoflavone but little if any ...
T. Shimosato +5 more
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