Results 1 to 10 of about 9,356 (215)

Application of fused-grid-based CYP-Template systems for genotoxic substances to understand the metabolisms [PDF]

Genes and Environment, 2023
Understanding of metabolic processes is a key factor to evaluate biological effects of carcinogen and mutagens. Applicability of fused-grid Template* systems of CYP enzymes (Drug Metab Pharmacokinet 2019, 2020, 2021, and 2022) was tested for three ...
Yasushi Yamazoe, Norie Murayama, Tomoko Kawamura, Takashi Yamada   +3 more
doaj   +2 more sources

Deciphering the molecular networks of 3-methylcholanthrene-induced clear cell renal cell carcinoma through multi-omics integration [PDF]

Scientific Reports
Exposure to 3-Methylcholanthrene (3-MC) may be associated with the development and progression of clear cell renal cell carcinoma (ccRCC); however, its underlying molecular mechanisms remain unclear.
Yuzhe Su, Peihuang Chen, Yaoan Wen, Jiangbin Yang, Yeda Chen, Shaoxing Zhu, Shuyuan Zhan, Song Zheng   +7 more
doaj   +2 more sources

Curability difference between autochthonous mouse tumors and their transplants in association with immune gene expression. [PDF]

PLoS ONE
Compared with transplanted tumors, autochthonous tumors are difficult to cure using experimental radiation therapy in mice. Here we analyzed differences in immune-related gene expression profiles between mouse fibrosarcomas subcutaneously induced by 3 ...
Hiroshi Tanooka, Chie Kudo-Saito, Fumiko Chiwaki, Masamichi Ishiai, Kouichi Tatsumi, Hiroki Sasaki, Takahiro Ochiya   +6 more
doaj   +2 more sources

Assessment of Homologous Recombination System Gene Expression in Chemologically Induced Carcinogenesis In Vivo Models [PDF]

Current Issues in Molecular Biology
Understanding the molecular mechanisms of carcinogenesis, including disruptions in the homologous recombination system, is fundamental to understanding malignant transformation.
Matvey M. Tsyganov, Danna Zh. Bulatova, Anastasia A. Fedorenko, Dmitry M. Loos, Pavel E. Nikiforov, Irina A. Tsydenova, Aigerim A. Bayanbayeva, Zhansaya Sharipkhanova, Sofia S. Timoshenko, Marina K. Ibragimova   +9 more
doaj   +2 more sources

Role of Latrophilin‐1 and Latrophilin‐2 as Downstream Effectors of Androgen Receptor Signaling in Urothelial Tumorigenesis [PDF]

Cancer Reports
Background Accumulating evidence indicates a critical role of androgen receptor (AR) in the pathogenesis of male‐dominant urothelial cancer. Meanwhile, the functions of latrophilins (LPHNs), a subfamily of G protein‐coupled receptors, remain largely ...
Takuro Goto, Yuki Teramoto, Mohammad Amin Elahi Najafi, Masato Yasui, Gaku Yamamichi, Takuo Matsukawa, Hiroshi Miyamoto   +6 more
doaj   +2 more sources

Inhibition activity of Artemisia vulgaris L. on Bhas 42 cell transformation [PDF]

Scientific Reports
Several factors can contribute to cancer development. Various methods are in use for cancer treatment, although their complications can be a cause of concern. Artemisia vulgaris L.
Paweena Pitimontol, Sumet Kongkiatpaiboon, Suwalee Worakhunpiset, Onrapak Reamtong, Nathamon Kosoltanapiwat, Kraichat Tantrakarnapa, Rachaneekorn Mingkhwan, Nuttapohn Kiangkoo, Yanin Limpanont   +8 more
doaj   +2 more sources

Exploring the association between air pollutants and non-small cell lung cancer using network toxicology and machine learning [PDF]

Discover Oncology
Background Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide. The urgent need to understand its risk factors and develop effective treatment strategies drives ongoing research in this field.
Qiang Zhao, Zhiqiang Zhao, Kunpeng Du
doaj   +2 more sources

Characterization of a novel cell line established from mice gastrointestinal stromal model by chemical induction [PDF]

Translational Oncology
Background: Gastrointestinal stromal tumors (GISTs) are a type of tumor that originates from gastrointestinal mesenchymal tissue. Although several somatic or germline mutation GIST mice were established, however, there is still a lack of an authentic ...
Zhan Zhao, Shenghui Qiu, Xiangwei Zhang, Shijin Liu, Lu Wang, Hanyang Guan, Jiashuai He, Yangzhi Hu, Xiaobo Li, Simin Luo, Zuyang Chen, Tianmu Mo, Yiran Zhang, Xiaoxu Zhao, Yunlong Pan, Hui Ding, Jie Cao, Jinghua Pan   +17 more
doaj   +2 more sources

Effects of cysteamine on 3-methylcholanthrene - induced fibrosarcoma in mice [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2013
Understanding the biology, developing methods for prevention and treatment of tumors is of great importance. The present study was investigated protective effects of the cysteamine on 3-methylcholantrene-induced fibrosarcoma in mice.
DOGAN A, AKSU P, ERDAG D, BAYEZIT M, DOGAN E, OZCAN K   +5 more
doaj   +1 more source

Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice. [PDF]

PLoS ONE, 2014
Tumor recognition by immune effector cells is mediated by antigen receptors and a variety of adhesion and costimulatory molecules. The evidence accumulated since the identification of CD155 and CD112 as ligands for DNAM-1 in humans and mice has suggested
Yoko Nagumo, Akiko Iguchi-Manaka, Yumi Yamashita-Kanemaru, Fumie Abe, Günter Bernhardt, Akira Shibuya, Kazuko Shibuya   +6 more
doaj   +1 more source