Results 41 to 50 of about 5,900 (175)

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, Volume 67, Issue 1-2, January‐February 2026.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

Transcriptomic Profiling of HepaRG Cells During Differentiation and 3-Methylcholanthrene Induction Using Oxford Nanopore Direct RNA Sequencing

Data
The aryl hydrocarbon receptor (AhR) plays a crucial role in mediating xenobiotic responses, as well as regulating broader metabolic, differentiation, and stress response programs. In this study, we present a comprehensive long-read RNA sequencing dataset
Nataliya G. Luzgina, Svetlana N. Tarbeeva, Daniil D. Romashin, Konstantin G. Ptitsyn, Svetlana A. Khmeleva, Leonid K. Kurbatov, Sergey P. Radko, Anna S. Kozlova, Polina A. Veselova, Ekaterina V. Ilgisonis, Alexander L. Rusanov   +10 more
doaj   +1 more source

Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent

Lipids in Health and Disease, 2019
Background A healthy gastric mucosal epithelium exhibits tumor-suppressive properties. Gastric epithelial cell dysfunction contributes to gastric cancer development.
Wenting Hong, Fenghua Guo, Mingjie Yang, Dongke Xu, Ziyan Zhuang, Baolin Niu, Qianming Bai, Xiaobo Li   +7 more
doaj   +1 more source

Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
Macrophages stimulated by BCG significantly enhanced endothelial cell proliferation, migration, and tube formation. Mechanistically, this pro‐angiogenic activity was reliant on activating NF‐αB or other signaling pathways, which induced the upregulation of HIF‐1α and VEGFA.
Yuyang Hou, Yuxi Wang, Qiong Wu, Wenjing Du, Shanzhu Guo, Xinyu Chai, Yinan Wang, Huixin Liang, Hongyan Yuan, Jun Li, Dongmei Yan   +10 more
wiley   +1 more source

Exposure the Hazardous Potential of Quinalphos: An In‐Depth Analysis for Environmental and Biological Effects on Human Health

IET Systems Biology, Volume 20, Issue 1, January/December 2026.
This study elucidates pesticide docking onto proteins encoded by differentially expressed genes, revealing interaction networks involving chemicals, genes, proteins, drugs and diseases. It highlights structural insights, regulatory pathways and potential therapeutic or environmental implications, providing a comprehensive understanding of the ...
Jyoti Kant Choudhari, Biju Prava Sahariah, Anand Kumar Jayapal, Jyotsna Choubey, Abhishek Tripathi   +4 more
wiley   +1 more source

Induction of tyrosine aminotransferase in mice is inhibited by activated metabolites of ortho- aminoazotoluene

Вавиловский журнал генетики и селекции, 2015
Aminoazo dyes and other hepatocarcinogenic substances inhibit glucocorticoid-mediated induction of adaptive enzymes, including tyrosine aminotransferase (TAT), in mouse and rat liver. There is a specific relationship between the effect of a carcinogen on
V. I. Kaledin, S. I. Ilnitskaya, N. A. Popova, O. A. Koval, I. A. Pyshnaya, L. F. Gulyaeva   +5 more
doaj   +1 more source

Avenanthramide C From Oats Possibly Exerts Anti‐Inflammatory Effects in Human Umbilical Vein Endothelial Cells

Journal of Food Science, Volume 91, Issue 1, January 2026.
ABSTRACT Chronic kidney disease (CKD) is associated with inflammation and cardiovascular complications and is partly exacerbated by the uremic toxin indoxyl sulfate (IS). IS is known to activate the aryl hydrocarbon receptor (AhR) to promote vascular inflammation.
Hiroyuki Sasaki, Hirofumi Masutomi, Hajime Nagasawa, Yuma Matsumoto, Teruyuki Okuma, Tomoyuki Otsuka, Katsuyuki Ishihara, Yusuke Suzuki, Seiji Ueda   +8 more
wiley   +1 more source

The Carcinogenic Activity of Methylcholanthrene in Rats [PDF]

The American Journal of Cancer, 1940
Studies of induced Cysticercus sarcoma in rats have demonstrated (1) a direct relationship between the number of parasites in the host's liver and the duration of the latent period. An increase in the number of cysts decreased directly the average time interval before the onset of malignant disease and increased directly the probability of its ...
W. F. Dunning, M. R. Curtis, M. J. Eisen
openaire   +1 more source

Medicinal Plants and Lead Phytomolecules as Immunomodulators: An Updated Review

BioMed Research International, Volume 2026, Issue 1, 2026.
All therapeutic interventions aimed at modulating the immune response to pathogens, self‐antigens, carcinogens, or xenogeneic antigens are referred to as immunomodulation, which either prevents hyperactivation or restores the appropriate response of the immune system.
Gurdeep Singh, Vikas Sharma, Blessing Nnenna Udeh, Baisakhi Banerjee   +3 more
wiley   +1 more source

Water Carcinogenicity and Prevalence of HPV Infection in Esophageal Cancer Patients in Huaihe River Basin, China

Gastroenterology Research and Practice, 2018
Objective. The incidence of the upper gastrointestinal tumor has increased rapidly during recent decades. The relationship between local water pollution and the tumor is still not much clear, so this study was conducted to further investigate the local ...
Maliha Ghaffar, Jintao Li, Lei Zhang, Sara Khodahemmati, Minglian Wang, Yangjunqi Wang, Lijiao Zhao, Runqing Jia, Su Chen, Yi Zeng   +9 more
doaj   +1 more source