Results 61 to 70 of about 5,900 (175)

Role of Latrophilin‐1 and Latrophilin‐2 as Downstream Effectors of Androgen Receptor Signaling in Urothelial Tumorigenesis

Cancer Reports
Background Accumulating evidence indicates a critical role of androgen receptor (AR) in the pathogenesis of male‐dominant urothelial cancer. Meanwhile, the functions of latrophilins (LPHNs), a subfamily of G protein‐coupled receptors, remain largely ...
Takuro Goto, Yuki Teramoto, Mohammad Amin Elahi Najafi, Masato Yasui, Gaku Yamamichi, Takuo Matsukawa, Hiroshi Miyamoto   +6 more
doaj   +1 more source

Pharmacokinetics of mirodenafil, a new erectogenic, and its metabolite, SK3541, in rats: involvement of CYP1A1/2, 2B1/2, 2D subfamily, and 3A1/2 for the metabolism of both mirodenafil and SK3541

Journal of Pharmacy & Pharmaceutical Sciences, 2010
Purpose. This study was performed to find which types of hepatic CYP isoforms are responsible for the metabolism of mirodenafil (a new erectogenic) and one of its metabolite, SK3541, using various hepatic CYP inducers and inhibitors in rats.
Young Hee Choi, Young Sun Lee, Myung Gull Lee, Tae Kon Kim, Bong-Yong Lee   +4 more
doaj   +1 more source

Erythropoietin Promotes the Growth of Tumors Lacking Its Receptor and Decreases Survival of Tumor-Bearing Mice by Enhancing Angiogenesis

Neoplasia: An International Journal for Oncology Research, 2008
Erythropoietin (Epo), a known hematopoietic growth factor, has been reported to promote tumor growth and angiogenesis in Epo receptor (EpoR)–positive tumors, but its effects on EpoR-negative tumors have not been clearly shown.
Tatsuma Okazaki, Satoru Ebihara, Masanori Asada, Shinsuke Yamanda, Kaijun Niu, Hiroyuki Arai   +5 more
doaj   +1 more source

CT-2A neurospheres-derived high-grade glioma in mice: a new model to address tumor stem cells and immunosuppression

Biology Open, 2019
Recently, several promising treatments for high-grade gliomas (HGGs) failed to provide significant benefit when translated from the preclinical setting to patients. Improving the animal models is fundamental to overcoming this translational gap.
Matteo Riva, Roxanne Wouters, Akila Weerasekera, Sarah Belderbos, David Nittner, Dietmar R. Thal, Thaïs Baert, Roberto Giovannoni, Willy Gsell, Uwe Himmelreich, Marc Van Ranst, An Coosemans   +11 more
doaj   +1 more source

Enhancing radiotherapy response via intratumoral injection of a TLR9 agonist in autochthonous murine sarcomas

JCI Insight
Radiation therapy (RT) is frequently used to treat cancers, including soft-tissue sarcomas. Prior studies established that the toll-like receptor 9 (TLR9) agonist cytosine-phosphate-guanine oligodeoxynucleotide (CpG) enhances the response to RT in ...
Chang Su, Collin L. Kent, Matthew Pierpoint, Warren Floyd, Lixia Luo, Nerissa T. Williams, Yan Ma, Brian Peng, Alexander L. Lazarides, Ajay Subramanian, Jonathon E. Himes, Vincent M. Perez, Rosa D. Hernansaiz-Ballesteros, Kimberly E. Roche, Jennifer L. Modliszewski, Sara R. Selitsky, Mari L. Shinohara, Amy J. Wisdom, Everett J. Moding, Yvonne M. Mowery, David G. Kirsch   +20 more
doaj   +1 more source

Effect-directed analysis and nontarget screening for identifying AhR-active substances in black-tailed gull eggs from South Korea

Environment International
This study identifies major aryl hydrocarbon receptor (AhR) agonists in the eggs of black-tailed gulls (Larus crassirostris) from South Korea using effect-directed analysis and nontarget screening (NTS).
Jihyun Cha, Jiyun Gwak, Junghyun Lee, Sori Mok, Hyo-Bang Moon, Gi Myung Han, Sang Hee Hong, Jong Seong Khim, Seongjin Hong   +8 more
doaj   +1 more source

Effects of cysteamine, putrescine and cysteamine-putrescine combination on 3-methylcholanthrene-induced fibrosarcoma in mice [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2014
DOĞAN A, AKSU P, ERDAĞ D, ÖZCAN K, DOĞAN E   +4 more
doaj   +1 more source

The effects of cysteamine on the mice with the 3-methylcholanthrene - induced fibrosarcoma: investigation of the genotoxicity [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2013
AKSU P, DOGAN A, GUL S, KANICI A
doaj   +1 more source

20-Methylcholanthrene [PDF]

, 2020
openaire   +1 more source

Novel insights into SNORD-78 and miR-122-5P the predicted diagnostic indexes of lung cancer: drug-loaded liposome formulations competing methylcholanthrene-induced lung cancer

Cancer Nanotechnology
Micro-RNAs (mi-RNAs) can regulate various tumor suppressor genes or oncogenes thus they were monitored in various types of cell carcinoma. Lung cancer extensive progress has led not only to understanding the molecular pathways governing human lung cancer,
Mai O. Kadry, Rehab M. Abdel-Megeed
doaj   +1 more source