Results 61 to 70 of about 9,356 (215)

Avenanthramide C From Oats Possibly Exerts Anti‐Inflammatory Effects in Human Umbilical Vein Endothelial Cells

Journal of Food Science, Volume 91, Issue 1, January 2026.
ABSTRACT Chronic kidney disease (CKD) is associated with inflammation and cardiovascular complications and is partly exacerbated by the uremic toxin indoxyl sulfate (IS). IS is known to activate the aryl hydrocarbon receptor (AhR) to promote vascular inflammation.
Hiroyuki Sasaki, Hirofumi Masutomi, Hajime Nagasawa, Yuma Matsumoto, Teruyuki Okuma, Tomoyuki Otsuka, Katsuyuki Ishihara, Yusuke Suzuki, Seiji Ueda   +8 more
wiley   +1 more source

Induction of tyrosine aminotransferase in mice is inhibited by activated metabolites of ortho- aminoazotoluene

Вавиловский журнал генетики и селекции, 2015
Aminoazo dyes and other hepatocarcinogenic substances inhibit glucocorticoid-mediated induction of adaptive enzymes, including tyrosine aminotransferase (TAT), in mouse and rat liver. There is a specific relationship between the effect of a carcinogen on
V. I. Kaledin, S. I. Ilnitskaya, N. A. Popova, O. A. Koval, I. A. Pyshnaya, L. F. Gulyaeva   +5 more
doaj   +1 more source

Medicinal Plants and Lead Phytomolecules as Immunomodulators: An Updated Review

BioMed Research International, Volume 2026, Issue 1, 2026.
All therapeutic interventions aimed at modulating the immune response to pathogens, self‐antigens, carcinogens, or xenogeneic antigens are referred to as immunomodulation, which either prevents hyperactivation or restores the appropriate response of the immune system.
Gurdeep Singh, Vikas Sharma, Blessing Nnenna Udeh, Baisakhi Banerjee   +3 more
wiley   +1 more source

Investigating the Use of Diagnostic Genes in Integrated Monitoring with a Laboratory and Field Study on Flounder (Platichthys flesus)

Toxics
For many years, there has been increasing concern about the effects of the presence of hazardous substances in the environment. The chemical and biological effect (BE) monitoring of these pollutants has proven difficult due to low environmental ...
Michelle C. Giltrap, Michael J. Leaver, Kelly White, James G. Wilson, Atiqur Rahman, Adrian Maguire, Aidan D. Meade, Janina Baršiene, Craig D. Robinson   +8 more
doaj   +1 more source

Water Carcinogenicity and Prevalence of HPV Infection in Esophageal Cancer Patients in Huaihe River Basin, China

Gastroenterology Research and Practice, 2018
Objective. The incidence of the upper gastrointestinal tumor has increased rapidly during recent decades. The relationship between local water pollution and the tumor is still not much clear, so this study was conducted to further investigate the local ...
Maliha Ghaffar, Jintao Li, Lei Zhang, Sara Khodahemmati, Minglian Wang, Yangjunqi Wang, Lijiao Zhao, Runqing Jia, Su Chen, Yi Zeng   +9 more
doaj   +1 more source

Repression of Activated Aryl Hydrocarbon Receptor–Induced Transcriptional Activation by 5α-Dihydrotestosterone in Human Prostate Cancer LNCaP and Human Breast Cancer T47D Cells

Journal of Pharmacological Sciences, 2009
Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor.
Noriko Sanada, Yuka Gotoh, Rumiko Shimazawa, Carolyn M. Klinge, Ryoichi Kizu   +4 more
doaj   +1 more source

Biological J‐Coupling Spectroscopy at Low Magnetic Field

Small Science, Volume 5, Issue 11, November 2025.
The strong J(C,H)‐coupling from [2‐13C] pyruvate is exploited to measure the pyruvate‐to‐lactate conversion in cancer cells at low magnetic fields. This is combined with a parahydrogen‐induced polarizationprotocol optimized to provide a biocompatible solution with 20 000‐fold signal enhancement.
Gonzalo G. Rodriguez, Charlotte von Petersdorff‐Campen, Sergey Korchak, Oscar Sucre, Maria D. Santi, Josef Elsasser, Ruhuai Mei, Lisa M. Fries, Jan Felger, Andrea Markus, Frauke Alves, Stefan Glöggler   +11 more
wiley   +1 more source

Author Correction: Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation

Scientific Reports, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Chih-Cheng Chang, Kuo-How Huang, Sung-Po Hsu, Yuan-Chii G. Lee, Yuh-Mou Sue, Shu-Hui Juan   +5 more
doaj   +1 more source

Targeted Therapies in the Most Common Advanced Solid Tumors, Drug Resistance, and Counteracting Progressive Micrometastatic Disease: The Next Frontier of Research

MedComm, Volume 6, Issue 10, October 2025.
In TME, undetectable DCCs (panel A) join with a low tumor burden along with low immune suppression, that favor successful immune manipulation through immune suppression inhibiting immune‐therapy. This moves the immune balance toward the immune response and likely makes more stable the dormant state of DCCs in the unstable metastatic niche and/or allows
Andrea Nicolini, Paola Ferrari, Roberto Silvestri, Dario A. Bini   +3 more
wiley   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, Volume 2, Issue 3, September 2025.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source