Results 81 to 90 of about 9,356 (215)

Neonatal thymectomy and tumor induction with methylcholanthrene in mice

, 1966
Methylcholanthrene was administered intradermally to adult normal and neonatally thymectomized mice. The incidence, latency period, growth rate, and histological type of the developing tumors were not significantly different for thymectomized mice as ...
Balner, H., Dersjant, H.
core  

Pharmacokinetics of mirodenafil, a new erectogenic, and its metabolite, SK3541, in rats: involvement of CYP1A1/2, 2B1/2, 2D subfamily, and 3A1/2 for the metabolism of both mirodenafil and SK3541

Journal of Pharmacy & Pharmaceutical Sciences, 2010
Purpose. This study was performed to find which types of hepatic CYP isoforms are responsible for the metabolism of mirodenafil (a new erectogenic) and one of its metabolite, SK3541, using various hepatic CYP inducers and inhibitors in rats.
Young Hee Choi, Young Sun Lee, Myung Gull Lee, Tae Kon Kim, Bong-Yong Lee   +4 more
doaj   +1 more source

Evaluation of the Response of Bufo arenarum larvae to 20-Methylcholanthrene

, 1970
We inoculated 214 animals with a 20-Methylcholanthrene suspension in olive oil. The first reaction, 3 to 9 days after inoculation, is an intensive epithelial hyperplasia with cellular disorientation, anisocytosis and increased mitotic activity limited to
Matos, Elena L., Sacerdote de Lustig, Eugenia   +1 more
core   +1 more source

A highly efficient synthesis of 3-methylcholanthrene

, 1993
A five-step synthesis of 3-methylcholanthrene (1) has been achieved starting from 5-methylhomophthalic anhydride and N,N-diethyl-1-naphthamide in 55% over all yield.
Thanasis Gimisis, Masato Koreeda
core   +1 more source

Erythropoietin Promotes the Growth of Tumors Lacking Its Receptor and Decreases Survival of Tumor-Bearing Mice by Enhancing Angiogenesis

Neoplasia: An International Journal for Oncology Research, 2008
Erythropoietin (Epo), a known hematopoietic growth factor, has been reported to promote tumor growth and angiogenesis in Epo receptor (EpoR)–positive tumors, but its effects on EpoR-negative tumors have not been clearly shown.
Tatsuma Okazaki, Satoru Ebihara, Masanori Asada, Shinsuke Yamanda, Kaijun Niu, Hiroyuki Arai   +5 more
doaj   +1 more source

CT-2A neurospheres-derived high-grade glioma in mice: a new model to address tumor stem cells and immunosuppression

Biology Open, 2019
Recently, several promising treatments for high-grade gliomas (HGGs) failed to provide significant benefit when translated from the preclinical setting to patients. Improving the animal models is fundamental to overcoming this translational gap.
Matteo Riva, Roxanne Wouters, Akila Weerasekera, Sarah Belderbos, David Nittner, Dietmar R. Thal, Thaïs Baert, Roberto Giovannoni, Willy Gsell, Uwe Himmelreich, Marc Van Ranst, An Coosemans   +11 more
doaj   +1 more source

3-Methylcholanthrene does not induce in vitro xenobiotic metabolism in spiny lobster hepatopancreas, or affect in vivo disposition of benzo[a]pyrene

, 1984
1. Administration of 3-methylcholanthrene (10 mg/kg) i.m. to spiny lobsters, Panulirus argus, did not cause induction of the cytochrome P-450 content of hepatopancreas microsomes. 2.
James, MO, Little, PJ
core   +1 more source

Preparation and analysis of a lung microsomal fraction from control and 3-methylcholanthrene treated rats.

, 1981
In order to facilitate the homogenization of lung tissue it was previously incubated with collagenase during 30 minutes. Morphological observations were performed in order to ascertain the cell integrity. The enzymatically digested tissue was homogenized
Noël, Gaëtane, Roberfroid, Marcel, Remacle, Jean-François, Lambotte-Vandepaer, M, Mercier, Michel, Poncelet, F.   +5 more
core  

Enhancing radiotherapy response via intratumoral injection of a TLR9 agonist in autochthonous murine sarcomas

JCI Insight
Radiation therapy (RT) is frequently used to treat cancers, including soft-tissue sarcomas. Prior studies established that the toll-like receptor 9 (TLR9) agonist cytosine-phosphate-guanine oligodeoxynucleotide (CpG) enhances the response to RT in ...
Chang Su, Collin L. Kent, Matthew Pierpoint, Warren Floyd, Lixia Luo, Nerissa T. Williams, Yan Ma, Brian Peng, Alexander L. Lazarides, Ajay Subramanian, Jonathon E. Himes, Vincent M. Perez, Rosa D. Hernansaiz-Ballesteros, Kimberly E. Roche, Jennifer L. Modliszewski, Sara R. Selitsky, Mari L. Shinohara, Amy J. Wisdom, Everett J. Moding, Yvonne M. Mowery, David G. Kirsch   +20 more
doaj   +1 more source

Study on the Effect of Statolon on Methylcholanthrene Oncogenesis in Mice

, 1972
Subcutaneous methylcholanthrene oncogenesis was produced in two strains of mice and statolon, an interferon inducer, was administered at different treatment regimens and at doses only just sufficient to induce an antiviral state in the host.
Ervin T. Gláz
core   +1 more source