Results 71 to 80 of about 9,356 (215)
Advanced Science, Volume 12, Issue 31, August 21, 2025.Lung squamous cell carcinoma (LUSC) is often preceded by sequential premalignant lesions with an increasing probability of malignant progression. Using single‐cell RNA sequencing, the dynamic cellular evolution from normal lung to LUSC tissues is delineated; clonal structure of premalignant and malignant epithelium is reveled; the conversion of immune ...
Baohong Luo +16 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 8, Issue 7, Page 1229-1252, July 2025.Grafts used to construct lung cancer animal models come from various sources, primarily cell lines, patient‐derived tumor tissues, and circulating tumor cells. Based on the sources of grafts and research objectives, lung cancer animal models can be categorized into several types: chemical‐induced models, orthotopic transplantation models, heterotopic ...
Zixuan Yang +7 more
wiley +1 more source
Aryl hydrocarbon receptors in osteoclast lineage cells are a negative regulator of bone mass.
PLoS ONE, 2015 Aryl hydrocarbon receptors (AhRs) play a critical role in various pathological and physiological processes. Although recent research has identified AhRs as a key contributor to bone metabolism following studies in systemic AhR knockout (KO) or transgenic
Tai-yong Yu, Wei-jun Pang, Gong-she Yang
doaj +1 more source
MHC Intratumoral Heterogeneity May Predict Cancer Progression and Response to Immunotherapy
Frontiers in Immunology, 2018 An individual tumor can present intratumoral phenotypic heterogeneity, containing tumor cells with different phenotypes that do not present irreversible genetic alterations.
Irene Romero +7 more
doaj +1 more source
Studies on Leukemogenesis in RF Mice by Oral Administration of 20-methylcholanthrene. I. Induction of Leukemia by Oral Administration of 20-methylcholanthrene [PDF]
, 1964 1) RF mice were fed three times a week wih 0.1-0.15cc of 0.4 and 0.8% 20-methylcholanthrene in olive oil by means of a needle of a catheter. The mode of development of myelogenous and lymphocytic leukemias in these mice was studied by observation of the ...
Ko, Itsuo
core
, 1973 Following a single dose of 3-methylcholanthrene in rat liver the RNA polymerase activity of Mg++and Mn++/(NH4)2SO4- dependent forms is stimulated in isolated nuclei and particularly in the chromatin of extranucleolar fraction.
Claudia Greco, Umberto Ferrini
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MODIFICATION OF REPRODUCTIVE FUNCTION IN THE RAT BY 3-METHYLCHOLANTHRENE
Pharmacological Research, 1997 Repeated exposure of adult female Wistar rats to 3-methylcholanthrene (MC) (25 mg kg(-1) b.w., i.p., 2xwk, 1 mo) was associated with a significant increase in estrus cycle length. In addition, an increased frequency of females with constant diestrus and abnormal cycles was observed.
Konstandi, M. +5 more
openaire +3 more sources
, 1995 Hydroxylation of a meso-anthracenic carbon atom with subsequent formation of a reactive ester bearing a good leaving group (e.g., sulfate) has been proposed as a possible biochemical mechanism responsible for DNA binding, mutagenicity and tumorigenicity ...
Surh, Y. J. +2 more
core
Using methylcholanthrene-induced fibrosarcomas to study tumor immunology
, 2021 Mouse models of cancer are essential in furthering our understanding both of the mechanisms that drive tumor development and the immune response that develops in parallel, and also in providing a platform for testing novel anti-cancer therapies.
A. Gallimore +11 more
core +1 more source
, 1985 Susceptible BALB/c virgin female mice were treated with 3-methylcholanthrene in almond oil (0.5 %) by skin painting and killed at monthly intervals.
Francesco Squartini +2 more
core +1 more source