Results 21 to 30 of about 5,900 (175)
Identification and editing of stem-like cells in methylcholanthrene-induced sarcomas
OncoImmunology, 2019 The cancer stem cell (CSC) paradigm posits that specific cells within a tumor, so-called CSC-like cells, have differing levels of tumorigenicity and chemoresistance.
Emilie T. E. Gross +6 more
doaj +1 more source
OncoImmunology, 2017 The cytokine-induced SH2-containing protein CIS belongs to the suppressor of cytokine signaling (SOCS) protein family. Here, we show the critical role of CIS in suppressing natural killer (NK) cell control of tumor initiation and metastasis.
Eva M. Putz +9 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background The chemical carcinogen 3-methylcholanthrene (3MC) binds to the aryl hydrocarbon receptor (AHR) that regulates the expression of cytochrome P450 (CYP) enzymes as CYP1B1, which is involved in the oncogenic activation of environmental pollutants
Francesca Cirillo +10 more
doaj +1 more source
Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα
Molecules, 2018 Isopsoralen (IPRN), one of the main effective ingredients in Psoralea corylifolia Linn, has a variety of biological effects, including antiosteoporotic effects.
Luna Ge +3 more
doaj +1 more source
OncoImmunology, 2018 Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results from studies with the methylcholanthrene-induced GL261 mouse glioma.
Vassilis Genoud +7 more
doaj +1 more source
Enhancement of Bio-Protective Functions by Low Dose/Dose-Rate Radiation
Dose-Response, 2006 Effects of low-dose-rate gamma-irradiation on the process of tumorigenesis were investigated in mice treated with a carcinogenic agent or irradiated with high dose X-rays at a high dose rate.
Kazuo Sakai +2 more
doaj +1 more source
Aristolochic Acid Affects Upper Tract Urothelial Cancer Behavior through the MAPK Pathway
Molecules, 2019 The prevalence of upper tract urothelial carcinoma (UTUC) in Taiwan is relatively higher than thatin Western countries. Aristolochic acid (AA), which is widely used in traditional Chinese herbology, is now recognized to be one of the carcinogens for UTUC.
I-Hsuan Chen +8 more
doaj +1 more source
GFP transgenic medaka (Oryzias latipes) under the inducible cyp1a promoter provide a sensitive and convenient biological indicator for the presence of TCDD and other persistent organic chemicals. [PDF]
PLoS ONE, 2013 Persistent organic pollutants (POPs) are resistant to environmental degradation and can cause multitude of health problems. Cytochrome P450 1A (Cyp1a) is often up-regulated by POPs through the activation of aryl hydrocarbon receptor (AhR) pathway and is ...
Grace Hwee Boon Ng, Zhiyuan Gong
doaj +1 more source
The Role of Regulatory T Lymphocytes in Immune Control of MC-2 Fibrosarcoma
Acta Clinica Croatica, 2020 The role of T regulatory lymphocytes (Treg) particularly in cancer is well known. The goal of the present study was to determine the contribution of these lymphocytes in the regulation of anti-tumor immunity of CBA/HZgr mice against MC-2 fibrosarcoma ...
Tomislav Jukić +6 more
doaj +1 more source
Scientific Report on consumer health‐based guidance values for trifluoroacetic acid
EFSA Journal, Volume 24, Issue 7, July 2026.Abstract The European Commission asked EFSA to provide a scientific report according to Article 31 of Regulation (EC) No 178/2002, in conjunction with Regulation (EC) No 1107/2009, to revise consumer health‐based guidance values, i.e. acceptable daily intake (ADI) and acute reference dose (ARfD), for trifluoroacetic acid (TFA). EFSA launched a targeted
EFSA (European Food Safety Authority) +15 more
wiley +1 more source