Results 21 to 30 of about 9,356 (215)

Brain tumors induced in rats by human adenovirus type 12 [PDF]

, 1974
Oncogenesis of human adenovirus type 12 in the brain of rats was examined. Newborn rats of Sprague-Dawley and Donryu　strains were injected intracranially with human adenovirus type 12.　The incidence of intracranial tumors was 91% (30/33) in
Ogawa, Katsuo, Ohmori, Hiroyuki, Sonobe, Hiroshi, Murao, Tsuyoshi, Tsutsumi, Akira, Matsuo, Keisuke   +5 more
core   +1 more source

Modulation of CYP1A1 by PKC Inhibitors and TPA Pre-Treatments in MH1C1 Rat Hepatoma Cells Exposed to 3 -Methylcholanthrene [PDF]

, 2009
Cytochrome P4501A1 (CYP1A1), an enzyme known to metabolize polycyclic aromatic hydrocarbons, is regulated by the aryl hydrocarbon receptor (AhR). The involvement of protein kinase C (PKC) in the regulation of AhR signal transduction pathway, has been ...
De Pascale, C., Marengo, B., Ledda, S., Penco, S., Nitti, M., Siri, M., Bassi, A., Sanguineti, R., Catalano, M., Scanarotti, C., Domenicotti, C.   +10 more
core   +1 more source

Methylcholanthrene-Induced Sarcomas Develop Independently from NOX2-Derived ROS.

PLoS ONE, 2015
Reactive oxygen species (ROS) produced by the inducible NADPH oxidase type 2 (NOX2) complex are essential for clearing certain infectious organisms but may also have a role in regulating inflammation and immune response.
Maarten A Ligtenberg, Özcan Çınar, Rikard Holmdahl, Dimitrios Mougiakakos, Rolf Kiessling   +4 more
doaj   +1 more source

Influence of thyroid secretion on the in­duction of leukemia in Dba mice by methylcholanthrene [PDF]

, 1960
1) The influence of thyroid secretion upon the induction of leukemia in Dba/2 male mice by methylcholanthrene was investigated. Radiothyroidectomy significantly reduced the incidence of leukemia in these mice. This reduction in incidence did not occur if
Oda, Nobuo, Ida, Noriaki
core   +1 more source

Identification and editing of stem-like cells in methylcholanthrene-induced sarcomas

OncoImmunology, 2019
The cancer stem cell (CSC) paradigm posits that specific cells within a tumor, so-called CSC-like cells, have differing levels of tumorigenicity and chemoresistance.
Emilie T. E. Gross, Carlos D. Peinado, Yujin Jung, Semi Han, Beichen Liu, Endi K. Santosa, Jack D. Bui   +6 more
doaj   +1 more source

Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis

OncoImmunology, 2017
The cytokine-induced SH2-containing protein CIS belongs to the suppressor of cytokine signaling (SOCS) protein family. Here, we show the critical role of CIS in suppressing natural killer (NK) cell control of tumor initiation and metastasis.
Eva M. Putz, Camille Guillerey, Kevin Kos, Kimberley Stannard, Kim Miles, Rebecca B. Delconte, Kazuyoshi Takeda, Sandra E. Nicholson, Nicholas D. Huntington, Mark J. Smyth   +9 more
doaj   +1 more source

AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs)

Journal of Experimental & Clinical Cancer Research, 2019
Background The chemical carcinogen 3-methylcholanthrene (3MC) binds to the aryl hydrocarbon receptor (AHR) that regulates the expression of cytochrome P450 (CYP) enzymes as CYP1B1, which is involved in the oncogenic activation of environmental pollutants
Francesca Cirillo, Rosamaria Lappano, Leonardo Bruno, Bruno Rizzuti, Fedora Grande, Rita Guzzi, Sara Briguori, Anna Maria Miglietta, Miki Nakajima, Maria Teresa Di Martino, Marcello Maggiolini   +10 more
doaj   +1 more source

Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα

Molecules, 2018
Isopsoralen (IPRN), one of the main effective ingredients in Psoralea corylifolia Linn, has a variety of biological effects, including antiosteoporotic effects.
Luna Ge, Yazhou Cui, Kai Cheng, Jinxiang Han   +3 more
doaj   +1 more source

Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models

OncoImmunology, 2018
Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results from studies with the methylcholanthrene-induced GL261 mouse glioma.
Vassilis Genoud, Eliana Marinari, Sergey I Nikolaev, John C. Castle, Valesca Bukur, Pierre-Yves Dietrich, Hideho Okada, Paul R. Walker   +7 more
doaj   +1 more source

Enhancement of Bio-Protective Functions by Low Dose/Dose-Rate Radiation

Dose-Response, 2006
Effects of low-dose-rate gamma-irradiation on the process of tumorigenesis were investigated in mice treated with a carcinogenic agent or irradiated with high dose X-rays at a high dose rate.
Kazuo Sakai, Takaharu Nomura, Yasuhiro Ina   +2 more
doaj   +1 more source