Results 11 to 20 of about 5,900 (175)

In Vitro Effects of Cabazitaxel and Menadione on Cell Growth, Metabolism, and Transcriptomic Profile of Human Prostate Cancer Cell Lines. [PDF]

Prostate Cancer
Cabazitaxel is a second‐generation semisynthetic taxane approved for the treatment of prostate cancer. Vitamin K, an essential nutrient involved in blood coagulation and bone metabolism, has also been shown to have antineoplastic effects. However, no information is currently available regarding the combinatorial effects of cabazitaxel and menadione ...
Gómez-Rosas AL, Chirinos M, Noyola-Martínez N, Segovia-Mendoza M, Torres-Ramírez N, Romero-Córdoba S, Noriega LG, García-Olivares M, Larrea F, Barrera D.   +9 more
europepmc   +2 more sources

Dormant Metastases Exhibit a Unique Phenotype Primarily Promoted by the Ch25h Gene and Are Maintained in Dormancy by T Lymphocytes. [PDF]

MedComm (2020)
Significance: Immune‐controlled dormant metastases exhibit a unique phenotype, primarily promoted by the Ch25h gene, that can be exploited to discover new biomarkers, as well as the development of therapies to eradicate dormant metastases or control overt metastases.
Chamorro V, Algarra I, Sanz V, Pulido M, Romero I, Chico E, Millán M, Escaño-Maestre M, Botella P, Linares I, García-Lora ÁM.   +10 more
europepmc   +2 more sources

MyoRep: A Novel Reporter System to Detect Early Muscle Atrophy In Vitro and In Vivo. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Muscle atrophy occurs during physiological (i.e., fasting) and pathological conditions (i.e., cancer) and anticipates death. Since not all patients will undergo muscle wasting, it would be highly useful to identify them soon to intervene early.
Re Cecconi AD, Rizzi N, Barone M, Palo F, Lunardi M, Forti M, Maggi A, Ciana P, Terribile G, Chiappa M, Zentilin L, Piccirillo R.   +11 more
europepmc   +2 more sources

Role of biotransformation in the diazinon-induced toxicity in HepG2 cells and antioxidant protection by tetrahydrocurcumin

Toxicology Reports, 2023
Diazinon (DZN) is an insecticide extensively used to control pests in crops and animals. However, its indicriminated use may lead to liver damage in animals and humans. This study aimed to evaluate the toxicity of DZN (25–150 µM) on human hepatoblastoma (
Camila Araújo Miranda, Eduardo Morais Beretta, Layra Araújo Ferreira, Emmily Sousa da Silva, Beatriz Zimermano Coimbra, Priscila Tartari Pereira, Raul Ghiraldelli Miranda, Daniel Junqueira Dorta, Flávia Thomaz Verechia Rodrigues, Fábio Erminio Mingatto   +9 more
doaj   +1 more source

A method for measurement of nanogram quantities of 3-methylcholanthrene in stool samples.

Journal of Lipid Research, 1984
The carcinogen 3-methylcholanthrene can be produced from deoxycholic acid and is postulated by some investigators to play a role in the pathogenesis of colon carcinoma. The small quantities of this compound which could be carcinogenic have been difficult
W C Duane, J C Behrens, S G Kelly, A S Levine   +3 more
doaj   +1 more source

The promigratory activity of the matricellular protein galectin-3 depends on the activation of PI-3 kinase. [PDF]

PLoS ONE, 2011
Expression of galectin-3 is associated with sarcoma progression, invasion and metastasis. Here we determined the role of extracellular galectin-3 on migration of sarcoma cells on laminin-111.
Fabiana H M Melo, Diego Butera, Mara de Souza Junqueira, Daniel K Hsu, Ana Maria Moura da Silva, Fu-Tong Liu, Marinilice F Santos, Roger Chammas   +7 more
doaj   +1 more source

Osteotoxicity of 3-methylcholanthrene in fish [PDF]

Ecotoxicology and Environmental Safety, 2018
Many chemicals produced by human activities end up in the aquatic ecosystem causing adverse developmental and reproductive effects in aquatic organisms. There is evidence that some anthropogenic chemicals disturb bone formation and skeletal development but the lack of suitable in vitro and in vivo systems for testing has hindered the identification of ...
Laizé Vincent, Gavaia Paulo, Tarasco Marco, Viegas Michael, Caria Joana, Luis Nuno, Cancela M. Leonor   +6 more
openaire   +2 more sources

Expression of CYP2A3 mRNA and its regulation by 3-methylcholanthrene, pyrazole, and ß-ionone in rat tissues

Brazilian Journal of Medical and Biological Research, 2003
Cytochrome P450 (CYP) 2A enzymes are involved in the metabolism of numerous drugs and hormones and activate different carcinogens. Human CYP2A6, mouse CYP2A5 and rat CYP2A3 are orthologous enzymes that present high similarity in their amino acid sequence
A.B. Robottom-Ferreira, S.R. Aquino, R. Queiroga, R.M. Albano, L.F. Ribeiro Pinto   +4 more
doaj   +1 more source

The effects of polycyclic aromatic compounds (PACs) on mammalian ovarian function

Current Research in Toxicology, 2022
Polycyclic aromatic compounds (PACs) are a broad class of contaminants ubiquitously present in the environment due to natural and anthropogenic activities. With increasing industrialization and reliance on petroleum worldwide, PACs are increasingly being
Genevieve A Perono, James J Petrik, Philippe J Thomas, Alison C Holloway   +3 more
doaj   +1 more source

Methylcholanthrene-Induced Sarcomas Develop Independently from NOX2-Derived ROS.

PLoS ONE, 2015
Reactive oxygen species (ROS) produced by the inducible NADPH oxidase type 2 (NOX2) complex are essential for clearing certain infectious organisms but may also have a role in regulating inflammation and immune response.
Maarten A Ligtenberg, Özcan Çınar, Rikard Holmdahl, Dimitrios Mougiakakos, Rolf Kiessling   +4 more
doaj   +1 more source