Results 141 to 150 of about 3,554 (178)
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Pulmonary Carcinogenesis: Aryl Hydrocarbon Hydroxylase
1981Especially during the past two decades, there has been a growing awareness that exposure of individuals to exogenous environmental agents is responsible for various kinds of cancer. Chemical carcinogenesis in man was first documented in 1775 by the British physician Percival Pott, who attributed the high incidence of scrotal cancer in London chimney ...
Theodore L. McLemore, R. Russell Martin
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Aryl hydrocarbon hydroxylase and 16?-hydroxylase in cultured human lymphocytes
Biochemical Genetics, 1976Aryl hydrocarbon hydroxylase and 16alpha-hydroxylase were examined in intact, cultured human lymphocytes. The two microsomal mixed-function oxygenases had different pH optima and showed competitive inhibition for enzyme induction and activity. Population distributions were lognormal for both enzymes, giving apparent evidence for polygenic control ...
M L, Coomes +5 more
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Hydrocarbon-based oils as inducers of cutaneous aryl hydrocarbon hydroxylase
Toxicology Letters, 1982Petroleum-based oils applied to the skin of rats induced cutaneous aryl hydrocarbon hydroxylase activity. A heavy oil like Kuwait Crude induced benzo(a)pyrene (BaP) hydroxylase and diphenyloxazole (PPO) hydroxylase activities to levels obtained with Aroclor 1254, while a light oil like Fuel Oil No. 2 was less effective.
A D, Rahimtula, J F, Payne, I, Martins
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Subcellular localization of human placental aryl hydrocarbon hydroxylase
Toxicology and Applied Pharmacology, 1973Abstract Homogenates of human placentas were fractionated by a variety of differential centrifugation techniques. Prepared subfractions were assayed by ultrastructure analysis and marker enzyme quantitation. The lowest ratios of cytochrome oxidase/aryl hydrocarbon hydroxylase activities were observed in a 6.24 × 10 6 g -min sediment fraction ...
M R, Juchau, E A, Smuckler
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Aryl Hydrocarbon Hydroxylase Activity in Rat Submandibular Glands
Journal of Dental Research, 1986The activities of aryl hydrocarbon hydroxylase and 7-ethoxycoumarin O-de-ethylase in the rat submandibular gland, both of which are normally very low, were increased about 10- and 25-fold, respectively, by administration of 3-methylcholanthrene. The increased activity of aryl hydrocarbon hydroxylase was inhibited by 7,8-benzoflavone but little if any ...
K, Murakami +5 more
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Flavone Modulators of Rat Hepatic Aryl Hydrocarbon Hydroxylase
Pharmacology, 1985The cytochrome P-450-dependent aryl hydrocarbon hydroxylase (AHH) metabolizes a wide variety of endogenous and exogenous compounds to nontoxic metabolites and/or toxic products. We have utilized a series of 18 flavone modulators of AHH to distinguish and probe for different cytochrome P-450 isozymes in liver microsomes from control and 3 ...
F K, Friedman +3 more
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ACTIVITY OF ARYL HYDROCARBON HYDROXYLASE IN PSORIATIC SKIN
The Lancet, 1979The activity of aryl hydrocarbon hydroxylase (A.H.H.), a microsomal mono-oxygenase, was reduced in epidermis from both the psoriatic lesions and clinically normal lesion-free skin from psoriatic patients. Induction of epidermal A.H.H. activity by benzanthracene was also significantly less than normal in both psoriatic lesions and in clinically normal ...
P H, Chapman, M D, Rawlins, S, Shuster
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Placental aryl hydrocarbon hydroxylase activity and placental calcifications
Toxicology, 1992Induction of aryl hydrocarbon hydroxylase (AHH) activity in the placenta as a result of maternal exposure to polycyclic aromatic hydrocarbons contained in cigarette smoke has been well documented. Furthermore, calcifications are more prevalent in the placentas of pregnant smokers than in those of non-smokers.
G, Huel +6 more
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ARYL-HYDROCARBON-HYDROXYLASE INDUCIBILITY IN PATIENTS WITH CANCER
The Lancet, 1978Aryl-hydrocarbon-hydroxylase (A.H.H.) inducibility has been studied in the peripheral-blood lymphocytes of patients with squamous-cell lung cancer, of patients with cancer at other sites, and of controls matched for age, sex, social class, and smoking habits. The proportion of high inducers was significantly greater among patients with lung cancer (but
A E, Emery +4 more
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Aryl hydrocarbon hydroxylase activity in Yusho patients
Chemosphere, 1987Abstract We examined AHH activity in 40 Yusho patients in 1984–1985 and studied the relationship of enzyme activity to severity of skin symptoms, or concentration of PCBs in the blood. Basal and 3-methylcholanthrene (MC)-induced AHH activities and induction ratio (MC-induced/basal) in the patients were not statistically different from those in ...
J. Nagayama +5 more
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