Results 141 to 150 of about 17,003 (187)

Significance of prolyl hydroxylase 2 in the interference of aryl hydrocarbon receptor and hypoxia-inducible factor-1 alpha signaling.

Chemical Research in Toxicology, 2008
Hypoxia-inducible factor-1 alpha (HIF-1 alpha) and the aryl hydrocarbon receptor (AhR) work as environmental sensors in human tissues. These proteins are members of the helix-loop-helix/Per-ARNT-SIM transcription factor family and form heterodimers with ...
Anja Seifert, D. Katschinski, S. Tonack, B. Fischer, A. Navarrete Santos   +4 more
semanticscholar   +1 more source

Pulmonary Carcinogenesis: Aryl Hydrocarbon Hydroxylase

1981
Especially during the past two decades, there has been a growing awareness that exposure of individuals to exogenous environmental agents is responsible for various kinds of cancer. Chemical carcinogenesis in man was first documented in 1775 by the British physician Percival Pott, who attributed the high incidence of scrotal cancer in London chimney ...
R. Russell Martin, Theodore L. McLemore
openaire   +2 more sources

Comparison of pulmonary DNA adduct levels, measured by 32P-postlabelling and aryl hydrocarbon hydroxylase activity in lung parenchyma of smokers and ex-smokers.

Carcinogenesis, 1991
In order to compare pulmonary DNA adducts and aryl hydrocarbon hydroxylase (AHH) activity, we have measured these two parameters in non-neoplastic surgical lung parenchymal samples from four ex-smokers and 19 smokers, out of 20 patients operated for lung
O. Geneste, A. Camus, M. Castegnaro, S. Petruzzelli, P. Macchiarini, C. Angeletti, C. Giuntini, H. Bartsch   +7 more
semanticscholar   +1 more source

Aryl hydrocarbon hydroxylase activity in Yusho patients

Chemosphere, 1987
Abstract We examined AHH activity in 40 Yusho patients in 1984–1985 and studied the relationship of enzyme activity to severity of skin symptoms, or concentration of PCBs in the blood. Basal and 3-methylcholanthrene (MC)-induced AHH activities and induction ratio (MC-induced/basal) in the patients were not statistically different from those in ...
Junya Nagayama, Tomio Hirohata, Masakazu Asahi, Y. Nakamura, Chikako Kiyohara, M. Ikeda   +5 more
openaire   +2 more sources

The relationship between CYP1A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population.

Pharmacogenetics (London), 1998
Because aryl hydrocarbon hydroxylase (AHH) is considered to be responsible for the activation of benzo(a)pyrene and other polyaromatic hydrocarbons in cigarette smoke to carcinogens, it is important to examine CYP1A1 (AHH) activity in the determination ...
Chikako Kiyohara, Yoichi Nakanishi, S. Inutsuka, Koichi Takayama, N. Hara, Akira Motohiro, Keitaro Tanaka, Suminori Kono, Tomio Hirohata   +8 more
semanticscholar   +1 more source

Aryl Hydrocarbon Hydroxylase in Man and Lung Cancer

1978
Lung cancer is one of the leading causes of cancer deaths in most Western countries. In the United States it accounts for 33% of the cancer deaths in males and 11% of the cancer deaths in females. More males die from lung cancer than from the four next common cancer sites combined, i. e., colon, prostate, pancreas, and stomach cancer.
Gottfried Kellermann, Robert S. Fontana, Harold L. Moses, James R. Jett, Mieke Luy ten-Kellermann   +4 more
openaire   +3 more sources

Aryl Hydrocarbon Hydroxylase Activity “Of Mice and Humans” [PDF]

, 1983
The fate of a particular chemical in vivo depends on a delicate balance between those enzymes capable of potentiating the effects of the chemical and those enzymes capable of detoxifying it to non-reactive intermediates. Within a given tissue or cell, several potential pathways exist for the metabolism of most xenobiotics (see reviews 1,2).
R. E. Kouri, G. M. Connolly, R. A. Lubet, D. W. Nebert, Cindy E. McKinney, T. L. McLemore   +5 more
openaire   +1 more source

3,4,3',4'-Tetrachloro azoxybenzene and azobenzene: potent inducers of aryl hydrocarbon hydroxylase.

Science, 1976
Two unwanted contaminants, 3,4,3',4'-tetrachloroazoxybenzene (TCAOB) and 3,4,3',4'-tetrachloroazobenzene (TCAB), formed in the commercial synthesis of 3,4-dichloroaniline or of herbicides made from 3,4-dichloroaniline, were responsible for three ...
A. Poland, E. Clover, A. Kende, M. Decamp, C. Giandomenico   +4 more
semanticscholar   +1 more source

Questionable relation of aryl hydrocarbon hydroxylase to lung-cancer risk.

New England Journal of Medicine, 1977
To test whether the genetically determined trait, aryl hydrocarbon hydroxylase inducibility, affects susceptibility to lung cancer, we measured this trait in cultured lymphocytes from a normal population, patients with lung cancer and progeny of such ...
B. Paigen, H. Gurtoo, J. Minowada, L. Houten, R. Vincent, K. Paigen, N. B. Parker, E. Ward, N. Hayner   +8 more
semanticscholar   +1 more source

Subcellular localization of human placental aryl hydrocarbon hydroxylase

Toxicology and Applied Pharmacology, 1973
Abstract Homogenates of human placentas were fractionated by a variety of differential centrifugation techniques. Prepared subfractions were assayed by ultrastructure analysis and marker enzyme quantitation. The lowest ratios of cytochrome oxidase/aryl hydrocarbon hydroxylase activities were observed in a 6.24 × 10 6 g -min sediment fraction ...
Mont R. Juchau, Edward A. Smuckler
openaire   +3 more sources