Arylpiperazine Derivatives and Cancer: A New Challenge in Medicinal Chemistry [PDF]
PharmaceuticalsBackground: In recent decades, there has been a startling rise in the number of cancer patients worldwide, which has led to an amazing upsurge in the development of novel anticancer treatment candidates. On a positive note, arylpiperazines have garnered attention in cancer research due to their potential as scaffolds for developing anticancer agents ...
Ferdinando Fiorino +2 more
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Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine [PDF]
Archives of Biological Sciences, 2012 The derivatives of cinnamic acid and N-arylpiperazine show antibacterial activity. In this work the potential synergistic effect of cinnamyl derivatives of arylpiperazine in selected bacteria was investigated. The antibacterial activities of the derivatives were evaluated against Gram-positive bacteria: Staphylococcus aureus ...
Irena Novakovic +5 more
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Structural Aspects of Arylpiperazines as Aminergic GPCR Ligands. [PDF]
MoleculesArylpiperazines are considered a “privileged scaffold” in medical chemistry due to their versatility and modular structure, enabling modifications towards diverse molecular targets with desired potency, selectivity, and pharmacokinetic properties.
Bartyzel A, Cristóvão B, Kaczor AA.
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Photocatalysis and Kinetic Resolution by Lithiation to Give Enantioenriched 2-Arylpiperazines. [PDF]
Org Lett, 2023 Piperazines are important heterocycles in drug compounds. We report the asymmetric synthesis of arylpiperazines by photocatalytic decarboxylative arylation (metallaphotoredox catalysis) then kinetic resolution using n-BuLi/(+)-sparteine. This gave a range of piperazines with very high enantioselectivities.
Das A, Choi A, Coldham I.
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Interaction of Arylpiperazines with the Dopamine Receptor D2 Binding Site [PDF]
Arzneimittelforschung, 2011 The docking of several 1-benzyl-4-arylpiperazines to the dopamine receptor (DAR) D2 was examined. The results demonstrated that the interaction of protonated N1 of the piperazine ring with Asp 86 (III.32) and edge-to-face interactions of the aromatic ring of the arylpiperazine part of the ligand with Phe 178 (VI.44), Trp 182 (VI.48) and Tyr 216 (VII.58)
Šukalović, Vladimir +5 more
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Ionization constants and partition coefficients of 1-arylpiperazine derivatives
Journal of Pharmacy and Pharmacology, 1985 AbstractThe ionization constant (pKa and liposolubilities (log P) of fourteen 1-arylpiperazines were determined by n-octanol/buffer partition. pKa varied little across the entire series. Log P values ranged from less than 1 to about 2 for the highly lipophilic derivatives of the preset series.
S, Caccia, M H, Fong, R, Urso
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Novel Arylpiperazine Derivatives of Salicylamide with α1-Adrenolytic Properties Showed Antiarrhythmic and Hypotensive Properties in Rats. [PDF]
Int J Mol Sci, 2022 Żmudzka E +8 more
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Design, Synthesis and Biological Evaluation of Novel N-Arylpiperazines Containing a 4,5-Dihydrothiazole Ring. [PDF]
Pharmaceuticals (Basel), 2023 Andreozzi G +14 more
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Synthesis, bioactivity, and molecular docking of novel arylpiperazine derivatives as potential AR antagonists. [PDF]
Front Chem, 2022 Qi Y, Chen H, Chen S, Shen J, Li J.
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Molecular Research on Mental Disorders. [PDF]
Int J Mol Sci, 2023 Sowa-Kućma M, Stachowicz K.
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