Arylpiperazine Derivatives and Cancer: A New Challenge in Medicinal Chemistry [PDF]
PharmaceuticalsBackground: In recent decades, there has been a startling rise in the number of cancer patients worldwide, which has led to an amazing upsurge in the development of novel anticancer treatment candidates.
Angela Corvino +2 more
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Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties [PDF]
Molecules, 2022 Long-chain arylpiperazine scaffold is a versatile template to design central nervous system (CNS) drugs that target serotonin and dopamine receptors. Here we describe the synthesis and biological evaluation of ten new arylpiperazine derivatives designed ...
Margherita Mastromarino +8 more
doaj +8 more sources
Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine [PDF]
Archives of Biological Sciences, 2012 The derivatives of cinnamic acid and N-arylpiperazine show antibacterial activity. In this work the potential synergistic effect of cinnamyl derivatives of arylpiperazine in selected bacteria was investigated.
Novaković Irena +5 more
doaj +6 more sources
Molecules, 2014 A series of novel arylpiperazine derivatives was synthesized. The in vitro cytotoxic activities of all synthesized compounds against three human prostate cancer cell lines (PC-3, LNCaP, and DU145) were evaluated by a CCK-8 assay.
Fang Xu, Biyun Huang, Mu Yuan
exaly +4 more sources
Synthesis and Antitumor Activity of Novel Arylpiperazine Derivatives Containing the Saccharin Moiety
Molecules, 2017 Prostate cancer is a major public health problem worldwide. For the development of potential anti-prostate cancer agents, a series of novel arylpiperazine derivatives containing the saccharin moiety based on previous studies was designed, synthesized ...
Tao Sun, Hui-Yuan Ya, Mu Yuan
exaly +4 more sources
Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases [PDF]
Biomolecules, 2022 Most neurodegenerative diseases are multifactorial, and the discovery of several molecular mechanisms related to their pathogenesis is constantly advancing.
Thayssa Tavares da Silva Cunha +7 more
doaj +3 more sources
Molecules, 2011 In this work, a series of arylpiperazine derivatives were synthesized and screened by in vivo pharmacological trials. Among the tested compounds, 2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)-1-phenylethanone (18) and 2-(4-(2,3-dimethylphenyl)piperazin-
Yin Chen, Xiangqing Xu, Bi-Feng Liu
exaly +4 more sources
Synthesis, bioactivity, and molecular docking studies: novel arylpiperazine derivatives as potential new-resistant AR antagonists [PDF]
Frontiers in ChemistryThe majority of patients with androgen-dependent prostate cancer (PCa) develop resistance to hormone therapy after approximately 18–24 months of androgen deprivation therapy treatment.
Hua Jiang +4 more
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Synthesis, bioactivity, and molecular docking of novel arylpiperazine derivatives as potential AR antagonists [PDF]
Frontiers in Chemistry, 2022 Prostate cancer is one of the malignant tumors and the second most common malignant tumor in men. Clinically used androgen receptor (AR)–targeted drugs can antagonize androgen and inhibit tumor growth, but these drugs can cause serious resistance ...
Yueheng Qi +5 more
doaj +2 more sources
Structural Aspects of Arylpiperazines as Aminergic GPCR Ligands. [PDF]
MoleculesArylpiperazines are considered a “privileged scaffold” in medical chemistry due to their versatility and modular structure, enabling modifications towards diverse molecular targets with desired potency, selectivity, and pharmacokinetic properties.
Bartyzel A, Cristóvão B, Kaczor AA.
europepmc +4 more sources