Results 21 to 30 of about 1,055 (154)

Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties

, 2014
Many known 5-HT7 ligands contain either a serotonin-like or an arylpiperazine structure that, in published SAR studies, are generally supposed to bind the same receptor pocket. Conversely, we explored the hypothesis that two such moieties can co-exist in
Riccioni T., Cabri W., PALA, Daniele, Bartolucci S., Mor M., Tarzia G., Borsini F., MOR, Marco, Minetti P., Marzi M., Pala D., Cabri W, Spadoni G., Rivara S., Celona D., RIVARA, Silvia, Bedini A.   +16 more
core   +2 more sources

Neuroprotective properties of arylpiperazine-sulphonamides in in vitro models of Parkinson's disease [PDF]

, 2023
Introduction: Parkinson’s disease (PD) is a neurodegenerative disease characterised by the degeneration of dopaminergic neurons in the substantia nigra.
Kingslake, Alice, Soskic, Vukic, Iravani, Mahmoud   +2 more
core   +1 more source

A perspective on multi‐target drug discovery and design for complex diseases

Clinical and Translational Medicine, Volume 7, Issue 1, December 2018., 2018
AbstractDiseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for multiple targets from millions of compounds.
Rona R. Ramsay, Marija R. Popovic‐Nikolic, Katarina Nikolic, Elisa Uliassi, Maria Laura Bolognesi   +4 more
wiley   +1 more source

5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence

British Journal of Pharmacology, Volume 183, Issue 16, Page 4715-4734, August 2026.
Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli, Deborah Rudin, Dino Luethi, Matthias E. Liechti, Sabrine Bilel, Matteo Marti, Henrik Green, Manuela Carla Monti, Caitlyn Norman   +8 more
wiley   +1 more source

Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF‐7 and MDA‐MB‐231

Journal of Chemistry, Volume 2017, Issue 1, 2017., 2017
Recent drug discovery efforts are highly focused towards identification, design, and synthesis of small molecules as anticancer agents. With this aim, we recently designed and synthesized novel compounds with high efficacy and specificity for the treatment of breast tumors.
Vincenza Barresi, Carmela Bonaccorso, Domenico A. Cristaldi, Maria N. Modica, Nicolò Musso, Valeria Pittalà, Loredana Salerno, Cosimo G. Fortuna, Oliver Sutcliffe   +8 more
wiley   +1 more source

Data for: Synthesis and pharmacological evaluation of novel arylpiperazine oxicams derivatives as potent analgesics without ulcerogenicity

, 2019
Data for: Synthesis and pharmacological evaluation of novel arylpiperazine oxicams derivatives as potent analgesics without ulcerogenicityTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS
Szczęśniak-Sięga, B (via Mendeley Data), Szczęśniak-Sięga, Berenika   +1 more
core   +1 more source

Hit‐To‐Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira, Duarte Eduardo Pereira, Rafael Consolin Chelucci, Simone Michelan, Júlia Maria Fernandes Pituba, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Neide Maria Silva, Celso de Oliveira Rezende Júnior   +8 more
wiley   +1 more source

Synthesis of Some New Thiazole Derivatives and Their Biological Activity Evaluation

Journal of Chemistry, Volume 2015, Issue 1, 2015., 2015
New 2‐(4‐arylpiperazine‐1‐yl)‐N‐[4‐(2‐(4‐substituted phenyl)thiazol‐4‐yl)phenyl]acetamide derivatives were synthesized and evaluated for their antimicrobial and anticholinesterase activities. Acetylcholinesterase inhibitory activities of the compounds were found weak contrary to expectations. It is unlikely that antifungal activity of the compounds was
Leyla Yurttaş, Yusuf Özkay, Hülya Karaca Gençer, Ulviye Acar, Filomena Conforti   +4 more
wiley   +1 more source

Modeling Interactions of Alpha(1a) Adrenergic Receptor and Different Arylpiperazine Ligands

, 2012
Molecular modelling studies were undertaken in order to identify key interactions of selected ligands with alpha(1A) adrenergic receptor, responsible for their binding and presumably receptor activation.
Kostić-Rajačić, Slađana, Andrić, Deana, Šukalović, Vladimir, Senćanski, Milan, Došen-Mićović, Ljiljana, Šoškić, Vukić, Roglić, Goran   +6 more
core   +5 more sources

Copper Complexes with Arylated Triethylenetetramine Ligands: Reactivity Toward Dioxygen and Peroxides

European Journal of Inorganic Chemistry, Volume 29, Issue 17, 17 June 2026.
Here, we describe new Cu(I)/Cu(II) complexes based on arylated tren ligands and investigate their reactivity toward O2 and peroxides. Low‐temperature–stopped flow studies revealed the formation of transient copper–oxygen species, including superoxido, hydroperoxido, and alkylperoxido intermediates.
Chiara Eleonora Campi, Christian Würtele, Siegfried Schindler   +2 more
wiley   +1 more source