Results 131 to 140 of about 1,089 (172)

Novel arylpiperazines as selective α1-adrenergic receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2000
A novel series of arylpiperazines has been synthesized and identified as antagonists of alpha1a adrenergic receptor (alpha1a-AR) implicated in benign prostatic hyperplasia. These compounds selectively bind to membrane bound alpha1a-AR with K(i)s as low as 0.66 nM.
X, Li, W V, Murray, L, Jolliffe, V, Pulito   +3 more
openaire   +2 more sources

Intraocular Pressure Lowering Effects of Novel Arylpiperazine Derivatives

Journal of Ocular Pharmacology and Therapeutics, 1998
Arylpiperazine derivatives were synthesized and investigated in this study. Two animal models, including an intraocular pressure (IOP) recovery method and an alpha-chymotrypsin-induced glaucoma model, were used to determine the ocular pharmacological effects of the arylpiperazine derivatives.
C H, Chiang, T J, Chang, D W, Lu, A R, Lee   +3 more
openaire   +2 more sources

Modeling of the D₂ Dopamine Receptor Arylpiperazine Binding Site for 1‐{2‐[5‐(1H‐Benzimidazole‐2‐thione)]ethyl}‐4‐arylpiperazines.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Šukalović, Vladimir, Zlatović, Mario, Andrić, Deana, Roglić, Goran, Kostić Rajačić, Slađana, Šoškić, Vukić   +5 more
openaire   +4 more sources

The Interactions of the 5-HT3 Receptor with Arylpiperazine, Tropane, and Quinuclidine Ligands

Current Topics in Medicinal Chemistry, 2002
The serotonin 5-HT(3) receptor subtype is unique among the receptors for this neurotransmitter because it has been demonstrated to be a ligand-gated ion channel capable of mediating rapid intercellular communication. This review covers the authors work performed during more than a decade in the development of 5-HT(3) receptor ligands belonging to the ...
Cappelli, Andrea, Anzini, Maurizio, Vomero, Salvatore, Mennuni, L., Makovec, F., Hamon, M., De Benedetti, P. G., Menziani, M. C.   +7 more
openaire   +5 more sources

A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders

Current Drug Targets, 2022
Bhupinder Kumar
exaly  

Antihypertensive activity of 1-dimethylphosphinylmethyl-4-arylpiperazines

Journal of Medicinal Chemistry, 1974
E J, Glamkowski, J, Strupczewski, E, Wolf, D L, Woodward   +3 more
openaire   +2 more sources

Novel Arylpiperazine Derivatives of Salicylamide with α1-Adrenolytic Properties Showed Antiarrhythmic and Hypotensive Properties in Rats

International Journal of Molecular Sciences, 2023
Agata Siwek, Karolina Pytka, Małgorzata Wolak   +2 more
exaly  

Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases

Biomolecules, 2022
Carlos Alberto Manssour Fraga, François Noel, Thales Kronenberger   +2 more
exaly  

Antimalarials based on the arylpiperazine privileged substructure

2005
Based on a previous study, arylpiperazines (2-chlorophenylpiperazine, 2-ethoxyphenylpiperazine and phenylpiperazine) were found to be significantly more potent against the chloroquine-resistant (K1) strain than against the chloroquine-sensitive(DIO) strain.
openaire   +1 more source

Pharmacophore Comparison and Development of Recently Discovered Long Chain Arylpiperazine and Sulfonamide Based 5-HT7 Ligands

Mini-Reviews in Medicinal Chemistry, 2018
Kevin Tidgewell
exaly