Results 111 to 120 of about 1,055 (154)

Intraocular Pressure Lowering Effects of Novel Arylpiperazine Derivatives

Journal of Ocular Pharmacology and Therapeutics, 1998
Arylpiperazine derivatives were synthesized and investigated in this study. Two animal models, including an intraocular pressure (IOP) recovery method and an alpha-chymotrypsin-induced glaucoma model, were used to determine the ocular pharmacological effects of the arylpiperazine derivatives.
C H, Chiang, T J, Chang, D W, Lu, A R, Lee   +3 more
openaire   +2 more sources

Novel arylpiperazines as selective α1-adrenergic receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2000
A novel series of arylpiperazines has been synthesized and identified as antagonists of alpha1a adrenergic receptor (alpha1a-AR) implicated in benign prostatic hyperplasia. These compounds selectively bind to membrane bound alpha1a-AR with K(i)s as low as 0.66 nM.
X, Li, W V, Murray, L, Jolliffe, V, Pulito   +3 more
openaire   +2 more sources

The Interactions of the 5-HT3 Receptor with Arylpiperazine, Tropane, and Quinuclidine Ligands

Current Topics in Medicinal Chemistry, 2002
The serotonin 5-HT(3) receptor subtype is unique among the receptors for this neurotransmitter because it has been demonstrated to be a ligand-gated ion channel capable of mediating rapid intercellular communication. This review covers the authors work performed during more than a decade in the development of 5-HT(3) receptor ligands belonging to the ...
Cappelli, Andrea, Anzini, Maurizio, Vomero, Salvatore, Mennuni, L., Makovec, F., Hamon, M., De Benedetti, P. G., Menziani, M. C.   +7 more
openaire   +5 more sources

Arylpiperazine substituted heterocycles as Selective α1a adrenergic antagonists

Bioorganic & Medicinal Chemistry Letters, 2002
Antagonists of the alpha(1)-adrenergic receptors (alpha(1)-ARs) are useful for the treatment of benign prostatic hyperplasia. A series of potent and subtype-selective alpha(1a)-AR antagonists has been synthesized, displaying in vitro binding affinity in the low the nanomolar range.
Haripada, Khatuya, Richard H, Hutchings, Gee-Hong, Kuo, Virginia L, Pulito, Linda K, Jolliffe, Xiaobing, Li, William V, Murray   +6 more
openaire   +2 more sources

Antihypertensive activity of 1-dimethylphosphinylmethyl-4-arylpiperazines

Journal of Medicinal Chemistry, 1974
E J, Glamkowski, J, Strupczewski, E, Wolf, D L, Woodward   +3 more
openaire   +2 more sources

Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-Arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases

Biomolecules, 2022
Carlos Fraga, François Noël, Thales Kronenberger   +2 more
exaly  

Design, Synthesis and Biological Evaluation of Novel Arylpiperazine Derivatives on Human Prostate Cancer Cell Lines

Chinese Chemical Letters, 2016
Mu Yuan
exaly  

Design, Synthesis and Biological Evaluation of Bitopic Arylpiperazine-Hexahydro-Pyrazinoquinolines as Preferential Dopamine D3 Receptor Ligands

Bioorganic Chemistry, 2018
Min Ji, Jin Cai
exaly  

Design, Synthesis and Biological Evaluation of Novel Arylpiperazine Derivatives on Human Prostate Cancer Cell Lines

Bioorganic and Medicinal Chemistry Letters, 2015
Fang Xu, Mu Yuan
exaly  

Design, Synthesis and Biological Evaluation of New Arylpiperazine Derivatives Bearing a Flavone Moiety as α1-Adrenoceptor Antagonists

Bioorganic and Medicinal Chemistry Letters, 2011
Xiaobing Wang
exaly