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SLC27, solute carrier 27 family, a long-chain fatty acid membrane transporters, in human cancers. [PDF]

Front Cell Dev Biol
Xu Z, Du J, Jiang WG, Martin TA.
europepmc   +1 more source

CXCR3 inhibitors for therapeutic interventions: current status and perspectives. [PDF]

Front Pharmacol
Huo R, Jiang Y, Zhang L, Du S, Zhou D.
europepmc   +1 more source

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Synthesis and Crystal Structures of Arylpiperazine Compounds (“Synthesis Crystal Structures Arylpiperazine” for Short)

Molecular Crystals and Liquid Crystals, 2017
Arylpiperazine derivatives referred in this article possessed antitumor activity, which were synthesized and crystallized through the gradual evaporation process.
Maocai Yan, Guoqiang Shangguan
exaly   +3 more sources

Arylpiperazine derivatives as serotoninergic ligands

, 2009
Serotonin is a neuromediator well known for its implication in mood regulation, anxiety, depression,insomnia as well as in normal human function such as sleep, sexual activity and appetite and recently it was demonstrated its involvement in the proliferation of human tumor cells.
FIORINO F, DE ANGELIS F, SEVERINO B, PERISSUTTI E, FRECENTESE F, ESPOSITO A, MASSARELLI, PAOLA, RENNER C, SANTAGADA V, CALIENDO G.   +9 more
core   +3 more sources

Synthesis and Cytotoxic Activity Evaluation of Novel Arylpiperazine Derivatives on Human Prostate Cancer Cell Lines

Molecules, 2014
A series of novel arylpiperazine derivatives was synthesized. The in vitro cytotoxic activities of all synthesized compounds against three human prostate cancer cell lines (PC-3, LNCaP, and DU145) were evaluated by a CCK-8 assay.
Fang Xu, Biyun Huang, Mu Yuan
exaly   +2 more sources

Interaction of Arylpiperazine Ligands With the Hydrophobic Part of the 5-HT1A Receptor Binding Site

Bioorganic and Medicinal Chemistry, 2006
A flexible docking of a series of arylpiperazine derivatives with structurally different aryl part to the binding site of a model of human 5-HT1A receptor was exercised.
Vladimir Sukalovic, Goran M Roglic, Mario V. Zlatović   +2 more
exaly   +2 more sources

Synthesis and Antitumor Activity of Novel Arylpiperazine Derivatives Containing the Saccharin Moiety

Molecules, 2017
Prostate cancer is a major public health problem worldwide. For the development of potential anti-prostate cancer agents, a series of novel arylpiperazine derivatives containing the saccharin moiety based on previous studies was designed, synthesized ...
Zhan Zhou, Tao Sun, Mu Yuan
exaly   +2 more sources

Asymmetric synthesis of 2-arylpiperazines

Bioorganic & Medicinal Chemistry Letters, 2014
An asymmetric synthesis of 2-arylpiperazines starting from phenacyl bromides, a variety of which are easily available, has been established. The synthesis features a CBS reduction of phenacyl bromide to provide optically enriched compounds, an SN2 reaction of 1,2,3-oxathiazolidine 2-oxides with an azide anion with invert of configuration, and ...
Satoshi, Yokoshima, Kazutoshi, Watanabe, Fumiaki, Uehara, Yoshihiro, Usui, Hiroshi, Tanaka   +4 more
openaire   +2 more sources

Design, Synthesis and Biological Activity Evaluation of Arylpiperazine Derivatives for the Treatment of Neuropathic Pain

Molecules, 2011
In this work, a series of arylpiperazine derivatives were synthesized and screened by in vivo pharmacological trials. Among the tested compounds, 2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)-1-phenylethanone (18) and 2-(4-(2,3-dimethylphenyl)piperazin-
Bi-Feng Liu, Yin Chen, Guisen Zhang
exaly   +2 more sources